D5321

D36 hydrate

≥98% (HPLC)

• Synonym(s): 5-(2-methoxyphenyl)-1-(2-methylpropyl)-1H-Indole-3-acetamide Hydrate
• Empirical Formula (Hill Notation): C₂₁H₂₄N₂O₂ · xH₂O
• CAS Number: 1228184-64-2
• Molecular Weight: 336.43 (anhydrous basis)
• MDL number: MFCD16875421
• UNSPSC Code: 51111800
• PubChem Substance ID: 329798803

Properties

• Assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: O.COc1ccccc1-c2ccc3n(CC(C)C)cc(CC(N)=O)c3c2
• InChI: 1S/C21H24N2O2.H2O/c1-14(2)12-23-13-16(11-21(22)24)18-10-15(8-9-19(18)23)17-6-4-5-7-20(17)25-3;/h4-10,13-14H,11-12H2,1-3H3,(H2,22,24);1H2
• InChI key: ZERKAKHVUQMJPW-UHFFFAOYSA-N

Description

Biochem/physiol Actions

D36 is an androgen receptor (AR) allosteric antagonist with inverse agonist properties. D36 inhibits both wild-type and agonist-induced AR activity and antagonized AR in a hormone-refractory model.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable