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C8990

Sp-8-pCPT-cAMPS

Name: Sp-8-pCPT-cAMPS
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic monophosphorothioate, Sp-isomer sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₄ClN₅O₅PS₂Na

CAS Number:

129693-13-6

Molecular Weight:

509.86

MDL number:

MFCD04113743

UNSPSC Code:

12352200

PubChem Substance ID:

24724452

Assay

≥98% (HPLC)

form

solid

packaging

vial of 5 μmol

solubility

H₂O: >1 mg/mL

shipped in

dry ice

storage temp.

−70°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([S-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

General description

Sp-8-pCPT-cAMPS is a nonhydrolyzable analog of cAMP with a p-chlorophenylthio moiety.

Application

Sp-8-pCPT-cAMPS has been used as an agonist for protein kinase A. It has also been used in the inhibition of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) in oligosphere cultures.

Biochem/physiol Actions

Sp-8-pCPT-cAMPS impairs PIP2 production by phosphatidylinositol 4-phosphate 5-kinase (PIP5K) inhibition. It may be involved in promoting remyelination in astrocytes and neurons. The lipophilicity feature of Sp-8-pCPT-cAMPS aids its cell entry for mediating remyelination. It may play a role in lowering Leishmania proliferation in in vitro studies.

Selective cAMP-dependent protein kinase (PKA) activator.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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