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A9141

Sigma-Aldrich

Antithrombin III from bovine plasma

lyophilized powder, 200-400 units/mg protein (E1%/280 = 6.5)

Synonym(s):

Factor Xa inhibitor, Heparin cofactor

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About This Item

CAS Number:
90170-80-2
EC Number:
290-516-4
MDL number:
MFCD00166632
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

bovine plasma

form

lyophilized powder

specific activity

200-400 units/mg protein (E1%/280 = 6.5)

solubility

water: 10 units/mL, clear, colorless

UniProt accession no.

P41361

shipped in

dry ice

storage temp.

−20°C

Gene Information

cow ... SERPINC1(540261)

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Biochem/physiol Actions

Serine protease inhibitor; Inhibitor of thrombin and activated factor X (Xa). Effective concentration equimolar with proteinase.

Linkage

Not to be confused with thrombin antiserum.

Unit Definition

One unit is the activity present in 0.1 mL of normal human pooled plasma tested in the presence of 0.1 unit of heparin.

Reconstitution

When reconstituted with 1.0 mL of deionized water, solution will contain a minimum of the stated activity in 0.1 M sodium chloride and 0.02 M Tris, pH 7.5.

Analysis Note

Homogeneous by gel electrophoresis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Silvia Grasso et al.
Cell death and differentiation, 27(2), 790-807 (2019-07-10)
Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13-15% of pediatric cancer death. Its intrinsic heterogeneity makes it difficult to target for successful therapy. The adaptor protein p140Cap/SRCIN1 negatively regulates tumor cell features and limits breast cancer

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