ALK-7 is a type I receptor of the serine/threonine kinases and is expressed in the adult central nervous system. Type I and II receptors bind ligands in the TGF-β superfamily.
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The Journal of biological chemistry, 271(48), 30603-30609 (1996-11-29)
Receptor serine-threonine kinases (RSTK) mediate inhibitory as well as stimulatory signals for growth and differentiation by binding to members of the transforming growth factor-beta (TGF-beta) superfamily. Over 12 different RSTKs have been isolated so far, displaying wide expression in peripheral
Human cDNA clones encoding four novel putative transmembrane protein serine/threonine kinases, denoted activin receptor-like kinase (ALK) -1, -2, -3 and -4, were obtained using a polymerase chain reaction (PCR)-based strategy. The PCR primers were designed based upon the sequence similarity
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