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M4627

Supelco

1-Methylnicotinamide chloride

analytical standard

Synonym(s):

N-Methylnicotinic acid amide chloride

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About This Item

Linear Formula:
C7H9N2OCl
CAS Number:
1005-24-9
Molecular Weight:
172.61
MDL number:
MFCD00060042
UNSPSC Code:
41116107
PubChem Substance ID:
329817903
NACRES:
NA.24

grade

analytical standard

Quality Level

100

Assay

≥97.5%

form

powder

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

application(s)

forensics and toxicology
veterinary
vitamins, nutraceuticals, and natural products

format

neat

SMILES string

[Cl-].C[n+]1cccc(c1)C(N)=O

InChI

1S/C7H8N2O.ClH/c1-9-4-2-3-6(5-9)7(8)10;/h2-5H,1H3,(H-,8,10);1H

InChI key

BWVDQVQUNNBTLK-UHFFFAOYSA-N

Related Categories

General description

1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.

Application

1-Methylnicotinamide chloride may be used as a standard in the quantification of 1-methylnicotinamide in urine samples using ion pairing reverse-phase high performance liquid chromatography (RP-HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Urinary excretion product of niacin metabolism

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000369166
0000369166
SLCR0536
SLCQ7504
SLCF5564

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Quantitation of the niacin metabolites 1-methylnicotinamide and l-methyl-2-pyridone-5-carboxamide in random spot urine samples, by ion-pairing reverse-phase HPLC with UV detection, and the implications for the use of spot urine samples in the assessment of niacin status
Creeke IP, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 817, 247-253 (2005)
Yoshitaka Tayama et al.
Drug metabolism and pharmacokinetics, 26(1), 94-101 (2010-11-19)
Aldehyde oxidase (AO) plays an important role in metabolizing antitumor and antiviral drugs, including methotrexate, cyclophosphamide and acyclovir. Green tea and its catechins have been shown to modulate the activities of various xenobiotic-metabolizing cytochrome P450 species, both in vivo and
Zuzana Országhová et al.
Redox report : communications in free radical research, 17(1), 1-7 (2012-02-22)
This study was focused on the monitoring how the anti-inflammatory substance, N(1)-methylnicotinamide (MNA), could influence oxidation and glycooxidation stress markers in rats under conditions of streptozotocin (STZ)-induced diabetes mellitus. Diabetes mellitus was induced in 60 male Wistar rats by intraperitoneal
Da Li et al.
Pharmaceutical biology, 51(1), 8-12 (2012-09-14)
Recent ecological evidence has showed a lag-correlation between the prevalence of diabetes and consumption of niacin (nicotinamide and nicotinic acid) in the US. Nicotinamide has been demonstrated to induce insulin resistance due to excess reactive oxygen species and methyl depletion
Misha Patel et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 921-922, 87-95 (2013-02-26)
Nicotinamide N-methyltransferase (NNMT, E.C. 2.1.1.1) N-methylates nicotinamide to produce 1-methylnicotinamide. Enhanced NNMT activity is a feature of many types of cancer, and has been linked to processes such as tumour metastasis, resistance to radiotherapy and tumour drug resistance. As such
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