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33993

Supelco

Doramectin

VETRANAL®, analytical standard

Synonym(s):

25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin

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About This Item

Empirical Formula (Hill Notation):
C50H74O14
CAS Number:
117704-25-3
Molecular Weight:
899.11
MDL number:
MFCD00894747
UNSPSC Code:
41116107
PubChem Substance ID:
329754732
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

agriculture
environmental

format

neat

storage temp.

−20°C

SMILES string

[H][C@@]12OC/C3=C\C=C\[C@H](C)[C@H](O[C@@H]4C[C@H](OC)[C@@H](O[C@@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)\C(C)=C\CC6C[C@@H](C[C@]7(O6)O[C@@H]([C@@H](C)C=C7)C8CCCCC8)OC(=O)[C@H](C=C(C)[C@H]1O)[C@@]23O

InChI

1S/C50H74O14/c1-27-13-12-16-34-26-57-47-42(51)30(4)21-37(50(34,47)54)48(53)60-36-22-35(63-49(25-36)20-19-29(3)45(64-49)33-14-10-9-11-15-33)18-17-28(2)44(27)61-41-24-39(56-8)46(32(6)59-41)62-40-23-38(55-7)43(52)31(5)58-40/h12-13,16-17,19-21,27,29,31-33,35-47,51-52,54H,9-11,14-15,18,22-26H2,1-8H3/b13-12+,28-17+,34-16+/t27-,29-,31-,32-,35?,36-,37-,38-,39-,40+,41+,42+,43-,44-,45-,46-,47+,49+,50+/m0/s1

InChI key

QLFZZSKTJWDQOS-TTXKVKCHSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Warning

Hazard Statements

H302,H361fd,H362,H410

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH8061
BCCJ1205
BCCD5184
BCCB5409
BCBT8576

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R Pérez et al.
Veterinary parasitology, 170(1-2), 112-119 (2010-03-04)
A study was done to compare plasma disposition kinetics and the fecal elimination profile of doramectin (DRM) after oral or intramuscular (IM) administration in horses. Ten clinically healthy horses, 328-502 kg body weight (bw), were assigned to 2 experimental groups
Dürdane Kaya et al.
Veterinaria italiana, 46(1), 51-56 (2010-04-15)
The authors used 14 New Zealand rabbits (5 naturally infested rabbits and 9 in-contact rabbits) for Sarcoptes scabiei treatment in this study. Signs, such as itchy ears, eyes, tail and abdominal skin, alopecia and pyoderma, were considered to be the
Ronald B Davey et al.
Experimental & applied acarology, 56(4), 365-374 (2012-02-22)
Analysis of doramectin concentration in blood serum of pastured cattle injected repeatedly (12 treatments) at two different dosage rates and 28-day intervals throughout the year was used to predict the probability that cattle fever ticks could successfully feed to repletion
Two new doramectin analogs from Streptomyces avermitilis NEAU1069: fermentation, isolation and structure elucidation.
Xiang-Jing Wang et al.
The Journal of antibiotics, 64(8), 591-594 (2011-06-16)
María Del Mar Gil-Díaz et al.
Journal of agricultural and food chemistry, 59(19), 10635-10640 (2011-08-09)
Doramectin is a veterinary drug used as an antihelminthic and is excreted mainly in the feces as the nonmetabolized drug. This study investigated the time profile of doramectin excretion in pig feces and the potential transfer and persistence of doramectin
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