It is recommended to store this product at -20°C. The long term stability of this product at -80°C has not been determined. However, there are no issues anticipated by storing this material at ultra-low temperatures.
DPP4-M
DPP IV Inhibitor
Synonym(s):
DPP IV Inhibitor, Dipeptidyl peptidase 4 Inhibitor, Gliptins
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About This Item
UNSPSC Code:
41116012
eCl@ss:
32160405
NACRES:
NC.07
Pricing and availability is not currently available.
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solution
Quality Level
NCBI accession no.
UniProt accession no.
Gene Information
human ... DPP4(1803)
General description
Dipeptidyl peptidase IV (DPP IV), a dimeric type II integral membrane glycoprotein, is a member of the family of prolyl-specific proteases. It is abundantly expressed in the epithelial and nonepithelial tissues. It is highly expressed in the kidney and the colon.[1]
Application
Research Category
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Biochem/physiol Actions
Dipeptidyl peptidase IV (DPP IV) controls insulin-stimulating hormones, glucagon-like peptide (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP). It′s a promising therapeutic target for type 2 diabetes (T2DM).[2] In addition to its catalytic action, DPP-4 also serves as a binding protein and a ligand of extracellular factors.[3] DPP-4 inhibition causes GLP-1 and GIP to have a prolonged activity, hence DPP-4 inhibitors help maintain glucose homeostasis. DPP IV inhibitors can improve glycemic control for a longer period when compared to early oral hypoglycemics.[4]
Storage and Stability
Upon arrival, store at 4°C. For long-term of more than 2 weeks, store at –20°C.
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The proline-specific dipeptidyl aminopeptidase IV (DPP IV, DPP-4, CD26), widely expressed in mammalians, releases X-Pro/Ala dipeptides from the N-terminus of peptides. DPP IV is responsible of the degradation of the incretin peptide hormones regulating blood glucose levels. Several families of
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Would our lab be able to store this product at -80 degrees celsius without compromising its composition?
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What is the concentration of this product and what is the working concentration suggested? Thanks!
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This product as provided at a concentration of 4 mM. The working concentration recommendations are 10 μl/mL of whole blood or 20 μl/mL of buffer, plasma, serum, or tissue culture medium. These are general usage recommendations, the optimal concentration is application- and/or system-dependent. The final working concentration should be empirically determined by the end user.
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