676494

VEGF Inhibitor, Je-11 - Calbiochem

• Synonym(s): VEGF Inhibitor, Je-11 - Calbiochem, (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
• Empirical Formula (Hill Notation): C₁₈₈H₂₇₃N₄₉O₅₇
• Molecular Weight: 4131.47
• UNSPSC Code: 12352200

Properties

• Assay: ≥90% (HPLC)
• Quality Level: 100
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated (hygroscopic)
• color: white
• solubility: DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C

Description

General description

This product has been discontinued.

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/FLK-1) comprising residues 247-261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 (IC₅₀ = 500 nM on extracellular VEGFR-2 fragments; IC₅₀ = 30 µM on HUVEC).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Binds to VEGF and blocks its interaction with VEGFR-2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Piossek, C., et al. 1999. J. Biol. Chem.274, 5612.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 10-13 - German Storage Class 10 to 13