559276

Ryanodine

≥98% (HPLC), solid, Ca2+ release blocker, Calbiochem^®

• Synonym(s): Ryanodine, High Purity
• Empirical Formula (Hill Notation): C₂₅H₃₅NO₉
• CAS Number: 15662-33-6
• Molecular Weight: 493.55
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Ryanodine, High Purity, Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum.
• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: water: 1 mg/mL; methanol: 20 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C25H35NO9/c1-12(2)22(31)17(34-16(28)14-7-6-10-26-14)23(32)18(4)11-21(30)19(22,5)25(23,33)24(35-21)15(27)13(3)8-9-20(18,24)29/h6-7,10,12-13,15,17,26-27,29-33H,8-9,11H2,1-5H3/t13-,15+,17+,18-,19-,20-,21-,22+,23+,24+,25+/m0/s1
• InChI key: JJSYXNQGLHBRRK-YSOSZROBSA-N

Description

General description

Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum. Has many complex effects on Ca²⁺ transport and action in muscle.

Naturally occurring alkaloid that blocks the release of Ca²⁺ from the sarcoplasmic reticulum. Has many complex effects on Ca²⁺ transport and action in muscle. Purified from Ryanodine Mixture.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Ca2+ transport and action in muscle

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Sorrentino, V., and Volpe, P. 1993. Trends Pharmacol. Sci.14, 98.
Sabbadini, R., et al. 1992. J. Biol. Chem.267, 15475.
Feher, J.J., and Lipford, G.B. 1985. Biochim. Biophys. Acta813, 77.
Marban, E., and Wier, W.G. 1985. Circ. Res.56, 133.
Sukto, J.L., et al. 1985. Fed. Proc.44, 2984.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H302 + H312,H410
• Precautionary Statements: P264 - P273 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable