444252

MMP-9/MMP-13 Inhibitor I

The MMP-9/MMP-13 Inhibitor I, also referenced under CAS 204140-01-2, controls the biological activity of MMP-9/MMP-13. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• Synonym(s): MMP-9/MMP-13 Inhibitor I, N-Hydroxy-1-(4-methoxyphenyl)sulfonyl-4-(4-biphenylcarbonyl)piperazine-2-carboxamide
• Empirical Formula (Hill Notation): C₂₅H₂₅N₃O₆S
• CAS Number: 204140-01-2
• Molecular Weight: 495.55
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: methanol: 1 mg/mL; DMSO: 100 mg/mL
• shipped in: ambient
• storage temp.: −20°C

Description

General description

A cell-permeable and highly, piperazine-based potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).

A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 (IC₅₀ = 900 pM) and MMP-13 (IC₅₀ = 900 pM). Inhibits MMP-1 and MMP-3 at much higher concentrations (IC₅₀ = 43 nM and 23 nM, respectively). Also acts as an inhibitor of MMP-7 (IC₅₀ = 930 nM).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
MMP-9

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 900 pM against both MMP-9 and MMP-13

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Cheng, M., et al. 2000. J. Med. Chem.43, 369.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable