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1.01656

SAFC

Benzonase® purity grade II (>90%) for biotechnology

Synonym(s):

Endonuclease from Serratia marcescens

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About This Item

CAS Number:
9025-65-4
Enzyme Commission number:
3.1.30.2 (BRENDA, IUBMB)
MDL number:
MFCD00131010
UNSPSC Code:
12352202
Pricing and availability is not currently available.

biological source

Serratia marcescens

Quality Level

100

recombinant

expressed in E. coli

sterility

non-sterile

Assay

≥90% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

≥250 units, pH 8.0, 37 °C

concentration

≥250 units/μL

impurities

≤10 CFU in 100 000 U Colony count (Yeasts and moulds)
≤10 CFU in 100 000 U Colony count (aerobic bacteria)
not detectable Proteases

color

clear
 colorless

pH

8 (25 °C in H2O)

application(s)

pharma/biopharma processes

foreign activity

foreign activity ≥1.0 x 10^6 units (calc. on protein)

shipped in

dry ice

storage temp.

−20°C

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General description

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.
We offer a range of high quality critical raw materials plus the documentation and expertise to help our customers meet stringent regulatory requirements. Our SAFC® portfolio of high-quality products withstands strict quality control procedures.

Application

Benzonase® purity grade II (>90%) for biotechnology is the technical grade in our Benzonase® product portfolio. All Benzonase® endonuclease products share the same amino acid sequence (proven by LC-MS/MS mass spectrometry), robustness and activity. The technical grade can be used to optimize the production / testing process before using one of our GMP grade during verification and manufacturing process.
Used for the removal of nucleic acid from protein samples.

Biochem/physiol Actions

Digests native or heat-denatured DNA and RNA.

Packaging

500,000 Units5,000,000 Units

Legal Information

Benzonase is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

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Articles

DNA/RNA Removal in Viral Production

Benzonase®endonuclease efficiently removes nucleic acid contaminants from viral production, crucial for cell and gene therapies and vaccines.

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