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06-983

Sigma-Aldrich

Anti-GADS Antibody

Upstate®, from rabbit

Synonym(s):

Anti-GADS, Anti-GRAP-2, Anti-GRB2L, Anti-GRBLG, Anti-GRID, Anti-GRPL, Anti-GrbX, Anti-Grf40, Anti-Mona, Anti-P38

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_004810

UniProt accession no.

O75791

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... GRAP2(9402)

Specificity

GADS

Immunogen

KLH-conjugated, synthetic peptide corresponding to amino acids 174-188 of murine GADS (GEEIRPSVNRKLSDH)

Application

Anti-GADS Antibody is an antibody against GADS for use in IP & WB.

Quality

routinely evaluated by immunoblot on Jurkat RIPA cell lysate

Target description

40kDa

Physical form

Format: Purified

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Eri Ishikawa et al.
Nature communications, 7, 12756-12756 (2016-09-28)
Thymic selection shapes an appropriate T cell antigen receptor (TCR) repertoire during T cell development. Here, we show that a serine/threonine kinase, protein kinase D (PKD), is crucial for thymocyte positive selection. In T cell-specific PKD-deficient (PKD2/PKD3 double-deficient) mice, the
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.
Jr-Wen Shui, Jonathan S Boomer, Jin Han, Jun Xu, Gregory A Dement, Guisheng Zhou, Tse-Hua Tan
Nature Immunology null
Luminal leptin inhibits L-glutamine transport in rat small intestine: involvement of ASCT2 and B0AT1.
Ducroc R, Sakar Y, Fanjul C, Barber A, Bado A, Lostao MP
American Journal of Physiology: Gastrointestinal and Liver Physiology null
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Roncagalli, R; Hauri, S; Fiore, F; Liang, Y; Chen, Z; Sansoni, A; Kanduri, K; Joly et al.
Nature Immunology null
Juris A Grasis et al.
Molecular and cellular biology, 30(14), 3596-3609 (2010-05-12)
In vitro data have suggested that activation of the inducible T-cell kinase (ITK) requires an interaction with the adaptor protein SLP-76. One means for this interaction involves binding of the ITK SH3 domain to the polyproline-rich (PR) region of SLP-76.
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