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860536P

Avanti

Sphinganine-1-Phosphate (d18:0)

Avanti Research™ - A Croda Brand 860536P, powder

Synonym(s):

D-erythro-sphinganine-1-phosphate

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About This Item

Empirical Formula (Hill Notation):
C18H40NO5P
CAS Number:
19794-97-9
Molecular Weight:
381.49
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 mg (860536P-1mg)
pkg of 1 × 5 mg (860536P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 860536P

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@](CCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O

InChI

1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1

InChI key

YHEDRJPUIRMZMP-ZWKOTPCHSA-N

General description

Sphinganine-1-Phosphate (SA1P) is a bioactive lipid present in mammals. It is produced from the sphingoid base, sphinganine in the presence of sphingosine kinase (SPHK).

Application

Sphinganine-1-Phosphate (d18:0) has been used as a reference standard in ultra performance liquid chromatography coupled to a mass spectrometry. It is suitable for use as an internal standard for ultra high performance liquid chromatography for the quantification of blood and muscle sphingolipid. Sphinganine-1-phosphate (d18:0) is also suitable for use as standard in liquid chromatography tandem mass spectrometry.

Biochem/physiol Actions

Sphinganine-1-Phosphate (SA1P) is an important marker for cancer and immune system disorders studies. It elicits protective functionality in hepatic ischemia. Elevated levels of SA1P is observed in hepatocellular carcinoma.

Packaging

5 mL Amber Glass Screw Cap Vial (860536P-1mg)
5 mL Amber Glass Screw Cap Vial (860536P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with 13C-encoded natural S1P as internal standard
Mirzaian M, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 459(5), 36-44 (2016)
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time-and intensity-dependent manner
Baranowski M, et al.
European Journal of Applied Physiology, 115(5), 993-1003 (2015)
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma
Grammatikos G, et al.
Testing, 7(14), 18095-18095 (2016)
Metabolomic insights into system-wide coordination of vertebrate metamorphosis
Ichu T, et al.
BMC Developmental Biology, 14(1), 5-5 (2014)
Katja Jakobi et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Hepatocellular carcinoma (HCC) shows a remarkable heterogeneity and is recognized as a chemoresistant tumor with dismal prognosis. In previous studies, we observed significant alterations in the serum sphingolipids of patients with HCC. This study aimed to investigate the in vitro

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