B29806
1-Benzyl-4-piperidone
99%
Synonym(s):
1-Benzyl-4-oxopiperidine
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About This Item
Empirical Formula (Hill Notation):
C12H15NO
CAS Number:
Molecular Weight:
189.25
Beilstein:
128556
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
form:
liquid
Assay:
99%
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Quality Level
Assay
99%
form
liquid
refractive index
n20/D 1.541 (lit.)
bp
134 °C/7 mmHg (lit.)
density
1.021 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
O=C1CCN(CC1)Cc2ccccc2
InChI
1S/C12H15NO/c14-12-6-8-13(9-7-12)10-11-4-2-1-3-5-11/h1-5H,6-10H2
InChI key
SJZKULRDWHPHGG-UHFFFAOYSA-N
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General description
Application
1-Benzyl-4-piperidone is generally used as a building block in the synthesis of various medicinal compounds. Applications include the synthesis of:
- Spirocyclic furopyridines as haloperidol-sensitive σ receptor ligands.[3][4]
- Multi-target-directed donepezil + propargylamine + 8-hydroxyquinoline (DPH) hybrids for the treatment of Alzheimer′s disease.[2]
- Spiropiperidine iminohydantoin aspartyl protease inhibitors.[5]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
159.8 °F
Flash Point(C)
71 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Novel spiropiperidines as highly potent and subtype selective ?-receptor ligands. Part 1.
Maier CA and Wunsch B
Journal of Medicinal Chemistry, 45(2), 438-448 (2002)
Donepezil+ propargylamine+ 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Wang Li, et al.
European Journal of Medicinal Chemistry, 80(2), 543-561 (2014)
Synthesis and ? receptor affinity of regioisomeric spirocyclic furopyridines.
Miyata K, et al.
European Journal of Medicinal Chemistry, 83(2), 709-716 (2014)
Di-tert-butylsilylene-directed α-selective synthesis of 4-methylumbelliferyl T-antigen.
Imamura A, et al.
Organic Letters, 7(20), 4415-4418 (2005)
Chunmei Gao et al.
Bioorganic & medicinal chemistry, 16(18), 8670-8675 (2008-08-21)
A novel series of 10-benzyl-9(10H)-acridinones and 1-benzyl-4-piperidones were synthesized and tested for their in vitro antitumor activities against CCRF-CEM cells. Assay-based antiproliferative activity study using CCRF-CEM cell lines revealed that the acridone group and the substitution pattern on the benzene
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