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914460

Sigma-Aldrich

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride

≥95%

Synonym(s):

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride, N-(2-(2-(2-aminoethoxy)ethoxy)ethyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide hydrochloride, N-{2-[2-(2- Aminoethoxy)ethoxy]ethoxy}biotinamide hydrochloride, Amine-terminated biotin linker, Biotin-DOOA HCl, Biotinylation reagent

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About This Item

Empirical Formula (Hill Notation):
C16H31ClN4O4S
CAS Number:
862373-14-6
Molecular Weight:
410.96
UNSPSC Code:
12352116
NACRES:
NA.22

Quality Level

100

Assay

≥95%

form

powder

storage temp.

2-8°C

Application

1-Biotinyl-3,6-dioxa-8-octaneamine hydrochloride is a versatile biotinylated linker that can be incorporated into chemical tools via its terminal amino group. Labeling materials or proteins with biotin provides a means to enrich and capture targets from biological systems.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

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Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Wilke C de Vries et al.
ACS applied materials & interfaces, 9(48), 41760-41766 (2017-11-16)
We present the preparation of ligand-conjugated redox-responsive polymer nanocontainers by the supramolecular decoration of cyclodextrin vesicles with a thin redox-cleavable polymer shell that displays molecular recognition units on its surface. Two widely different recognition motifs (mannose-Concanavalin A and biotin-streptavidin) are
Zhiyuan Fang et al.
Chemical communications (Cambridge, England), 49(55), 6164-6166 (2013-06-04)
A direct ELISA was established for the fast detection of semicarbazide (SEM) using a novel biotin derivative. Without a tedious extraction procedure, as low as 0.07 μg L(-1) of SEM could be detected reproducibly. This assay has better recovery and
Benjamin Spangler et al.
ACS chemical biology, 14(4), 725-734 (2019-03-26)
Compartmentalization is a crucial facet of many biological systems, and key aspects of cellular processes rely on spatial segregation within the cell. While many drug targets reside in specific intracellular compartments, the tools available for assessing compound exposure are generally
Sebastian Pomplun et al.
Angewandte Chemie (International ed. in English), 58(11), 3542-3547 (2019-01-18)
We discovered N-pyrrolyl alanine derivatives as efficient reagents for the fast and selective Pictet-Spengler reaction with aldehyde-containing biomolecules. Other aldehyde-labeling methods described so far have several drawbacks, like hydrolytic instability, slow reaction kinetics or not readily available labeling reagents. Pictet-Spengler
Yali Yuan et al.
Chemical communications (Cambridge, England), 54(80), 11352-11355 (2018-09-25)
We have developed highly fluorescent, monolithic colloidal CdSe seeded CdS nanorod clusters comprising thousands of nanorods. Their use in the sandwich assay detection of a model protein yields a thousand-fold improvement in the detection limit compared to individual nanorods, making
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