900188
Poly(N-isopropyl acrylamide)
NHS ester end functionalized, average Mn 5,000
Synonym(s):
PNIPAM, polyNIPAM
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About This Item
Linear Formula:
C8H10NO4(C6H11NO)nH
UNSPSC Code:
12162002
NACRES:
NA.23
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Application
Poly(N-isopropyl acrylamide) (PolyNIPAM) is a stimuli-responsive polymer. This product features low polydispersity (PDI), which typically leads to better reproducibility in applications, and a terminal N-hydroxysuccinimide (NHS) functional group, allowing for rapid conjugation of biomolecules, small molecules, or other polymers. PolyNIPAM has been used in development of a variety of thermosensitive coated micro/nano materials, including thermoresponsive polymeric drug delivery systems.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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Avraham Halperin et al.
Langmuir : the ACS journal of surfaces and colloids, 28(48), 16623-16637 (2012-11-06)
Thermoresponsive tissue culture substrates based on PNIPAM brushes are used to harvest confluent cell sheets for tissue engineering. The prospect of clinical use imposes the utilization of culture medium free of bovine serum, thus suggesting conjugation with adhesion peptides containing
Shahrzad Rayatpisheh et al.
Macromolecular bioscience, 12(7), 937-945 (2012-04-27)
A new method for ultrathin grafting of pNIPAm on PDMS surfaces is introduced that employs plasma activation of the surface followed by thermal polymerization. This method is optimized for human primary SMC attachment and subsequent intact cell sheet detachment by
Umut Atakan Gurkan et al.
Advanced healthcare materials, 1(5), 661-668 (2012-11-28)
Stimuli responsive, smart interface materials are integrated with microfluidic technologies creating new functions for a broad range of biological and clinical applications by controlling the material and cell interactions. Local capture and on-demand local release of cells are demonstrated with
A C C Rotzetter et al.
Advanced materials (Deerfield Beach, Fla.), 24(39), 5352-5356 (2012-08-31)
Buildings can be effectively cooled by a bioinspired sweating-like action based on thermoresponsive hydrogels (PNIPAM), which press out their stored water when exceeding the lower critical solution temperature. The surface temperature is reduced by 15 °C compared to that of
Yan Xia et al.
Chemical communications (Cambridge, England), 49(25), 2566-2568 (2013-02-21)
Site-specific protein conjugates with RAFT polymers were synthesized using expressed protein ligation. Stable micelles were formed from both linear block copolymer and Y-shaped conjugates.
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Professor Mitsuhiro Ebara provides insights on several types of smart nanofiber mesh systems that have been explored for different drug delivery purposes.
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