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Sigma-Aldrich

6-Hydroxy-1-indanone

97%

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About This Item

Empirical Formula (Hill Notation):
C9H8O2
CAS Number:
62803-47-8
Molecular Weight:
148.16
MDL number:
MFCD00513530
UNSPSC Code:
12352100
PubChem Substance ID:
24882631
NACRES:
NA.22

Assay

97%

form

solid

mp

154-158 °C (lit.)

SMILES string

Oc1ccc2CCC(=O)c2c1

InChI

1S/C9H8O2/c10-7-3-1-6-2-4-9(11)8(6)5-7/h1,3,5,10H,2,4H2

InChI key

MOANRQDXNNXOLW-UHFFFAOYSA-N

Application

6-Hydroxy-1-indanone can be used in the synthesis of tetracyclic ketones intermediates during the total syntheses of (±)-frondosin C and (±)-8-epi-frondosin C. It can also be used in the synthesis of 1,4-dihydroindeno[1,2-c]pyrazoles, which can act like potent CHK-1 inhibitors, thereby inhibiting the growth of cancer cells.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H317,H319

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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"Cyanopyridyl containing 1, 4-dihydroindeno [1, 2-c] pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability"
Tong Y, et al.
Bioorganic & Medicinal Chemistry, 17(20), 5665-5670 (2007)
"Total syntheses of (?)-frondosin C and (?)-8-epi-frondosin C via a tandem anionic 5-exo dig cyclization?Claisen rearrangement sequence"
Li X. et al.
Tetrahedron, 63(09), 1899-1906 (2007)

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