531480

Fmoc-Ala-OH

95%, for peptide synthesis

• Synonym(s): N-(9-Fluorenylmethoxycarbonyl)-L-alanine, Fmoc-L-alanine
• Empirical Formula (Hill Notation): C₁₈H₁₇NO₄
• CAS Number: 35661-39-3
• Molecular Weight: 311.33
• Beilstein: 2225975
• EC Number: 252-660-6
• MDL number: MFCD00037139
• UNSPSC Code: 12352209
• PubChem Substance ID: 24877820
• NACRES: NA.26

Properties

• Product Name: Fmoc-Ala-OH, 95%
• Quality Level: 100
• Assay: 95%
• optical activity: [α]20/D −18°, c = 1 in DMF
• reaction suitability: reaction type: C-H Activation; reaction type: Fmoc solid-phase peptide synthesis; reagent type: ligand; reaction type: Peptide Synthesis
• mp: 147-153 °C (lit.)
• application(s): peptide synthesis
• functional group: Fmoc; amine; carboxylic acid
• storage temp.: 2-8°C
• SMILES string: C[C@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
• InChI: 1S/C18H17NO4/c1-11(17(20)21)19-18(22)23-10-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,11,16H,10H2,1H3,(H,19,22)(H,20,21)/t11-/m0/s1
• InChI key: QWXZOFZKSQXPDC-NSHDSACASA-N

Description

General description

Fmoc-Ala-OH also known as Fmoc-L-alanine, is a versatile reagent used in Fmoc solid-phase peptide synthesis.

Application

Fmoc-Ala-OH is commonly used :

• as a building block in the preparation of triazolopeptides , and azapeptides[1]
• in the synthesis of bis-cationic porphyrin peptides using the standard Fmoc solid-phase synthesis[2]
• to transform Mannich-adducts into α-halogenated amides without undergoing aziridination[3]

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves