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Sigma-Aldrich

Isobutyl nitrite

95%

Synonym(s):

2-Methylpropyl nitrite

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About This Item

Linear Formula:
(CH3)2CHCH2ONO
CAS Number:
542-56-3
Molecular Weight:
103.12
EC Number:
208-819-7
MDL number:
MFCD00002056
UNSPSC Code:
12352100
PubChem Substance ID:
24859648
NACRES:
NA.22

Quality Level

100

Assay

95%

form

liquid

refractive index

n20/D 1.373 (lit.)

bp

66-67 °C (lit.)

density

0.87 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CC(C)CON=O

InChI

1S/C4H9NO2/c1-4(2)3-7-5-6/h4H,3H2,1-2H3

InChI key

APNSGVMLAYLYCT-UHFFFAOYSA-N

Related Categories

General description

Isobutyl nitrite was extensively used as room odorizers. It is a popular recreational drug.

Application

Isobutyl nitrite was used to study inhalant-induced immunotoxicity.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Flam. Liq. 2 - Muta. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

-5.8 °F - closed cup

Flash Point(C)

-21 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Lindenmann et al.
Inhalation toxicology, 18(13), 1047-1049 (2006-09-13)
Methemoglobinemia usually results from exposure to oxidizing substances such as nitrates or nitrites. Iron within hemoglobin is oxidized from the ferrous (Fe2+) state to the ferric (Fe3+) state, resulting in the inability to transport oxygen and carbon dioxide. Clinically, this
Doanh C Tran et al.
Biochemical and biophysical research communications, 310(2), 439-445 (2003-10-03)
Inhalant nitrites are drugs of abuse that have been shown to enhance tumor growth rate in mice and are epidemiologically linked to an increased risk of Kaposi's sarcoma. Because nitrites produce nitric oxide, we hypothesized that their toxicological effects might
[Methemoglobinemia due to ingestion of isobutyl nitrite ('poppers')].
W G Zijlstra
Nederlands tijdschrift voor geneeskunde, 147(11), 522-523 (2003-04-08)
Isobutyl nitrite liberates nitric oxide which is not responsible for the immunotoxicity of the inhalant.
L S Soderberg et al.
Advances in experimental medicine and biology, 437, 265-268 (1998-07-17)
Steven G Turowski et al.
The AAPS journal, 9(3), E298-E305 (2007-10-06)
We examined the effects of acute isobutyl nitrite (ISBN) exposure on the activity of several hepatic enzymes. Two strains of adult male mice (Balb/c and C57BL/6) were exposed to 900 ppm ISBN or ambient air for 45 minutes. The enzyme
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