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229113

Sigma-Aldrich

Nuclear Fast Red

Synonym(s):

4-Amino-9,10-dihydro-1,3-dihydroxy-9,10-dioxo-2-anthracenesulfonic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C14H8NNaO7S
CAS Number:
6409-77-4
Molecular Weight:
357.27
Colour Index Number:
60760
EC Number:
229-088-0
MDL number:
MFCD00078493
UNSPSC Code:
12171500
PubChem Substance ID:
24853728
NACRES:
NA.47
Pricing and availability is not currently available.

form

powder

ε (extinction coefficient)

≥11000 at 515-540 nm in H2O at 0.01 g/L

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].Nc1c(O)c(c(O)c2C(=O)c3ccccc3C(=O)c12)S([O-])(=O)=O

InChI

1S/C14H9NO7S.Na/c15-9-7-8(12(18)14(13(9)19)23(20,21)22)11(17)6-4-2-1-3-5(6)10(7)16;/h1-4,18-19H,15H2,(H,20,21,22);/q;+1/p-1

InChI key

IFSXZLJQEKGQAF-UHFFFAOYSA-M

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Application

Nuclear fast red has been used to counterstain nuclei and renal collecting ducts.[1][2]
Suitable for determination of calcium
Used as a biological stain

Biochem/physiol Actions

Nuclear fast red dye has anthraquinonic nature and is used either alone or in combination with other dyes. It is mainly used for staining of nuclei.[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS2057
SHBQ7728
MKCB7399
MKBR3003V
MKBJ8443V

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Liu Y
EBioMedicine, 2, 1318-1330 (2015)
M M Rahman et al.
British journal of cancer, 100(3), 501-510 (2009-01-22)
The molecular pathogenesis of gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) remains to be elucidated. High-mobility group A (HMGA) proteins play important roles in the regulation of transcription, differentiation, and neoplastic transformation. In this study, the expression of HMGA1 and HMGA2 was
Florian R Fritzsche et al.
BMC cancer, 8, 381-381 (2008-12-23)
Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors
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