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S1820

Sigma-Aldrich

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt

≥98% (HPLC), lyophilized powder

Synonym(s):

PAR-1 (Protease-Activated Receptor) Selective Activating Peptide, PAR1-AP, SFLLRN-NH2

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About This Item

Linear Formula:
C34H57N11O8 · x CF3COOH
CAS Number:
Molecular Weight:
747.89 (free base basis)
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

Assay

≥98% (HPLC)

form

lyophilized powder

color

white

UniProt accession no.

storage temp.

−20°C

SMILES string

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O

InChI

1S/C34H57N11O8.C2HF3O2/c1-18(2)13-24(31(51)41-22(11-8-12-40-34(38)39)30(50)42-23(28(37)48)16-27(36)47)44-32(52)25(14-19(3)4)45-33(53)26(43-29(49)21(35)17-46)15-20-9-6-5-7-10-20;3-2(4,5)1(6)7/h5-7,9-10,18-19,21-26,46H,8,11-17,35H2,1-4H3,(H2,36,47)(H2,37,48)(H,41,51)(H,42,50)(H,43,49)(H,44,52)(H,45,53)(H4,38,39,40);(H,6,7)/t21-,22-,23-,24-,25-,26-;/m0./s1

InChI key

YICKZNIVMKPQPD-POCCEKOUSA-N

Gene Information

human ... IGF1R(3480)

Amino Acid Sequence

Ser-Phe-Leu-Leu-Arg-Asn-NH2

Application

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt has been used as a protease-activated receptor 1 (PAR-1) selective activating peptide.

Biochem/physiol Actions

Ser-Phe-Leu-Leu-Arg-Asn-amide trifluoroacetate salt (SFLLRN) acts as a protease-activated receptor 1 (PAR-1) specific agonist peptide.
Thrombin receptor activating peptide (TRAP).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nicola Maggio et al.
Hippocampus, 24(8), 1030-1038 (2014-04-23)
Thrombin and other clotting factors regulate long-term potentiation (LTP) in the hippocampus through the activation of the protease activated receptor 1 (PAR1) and consequent potentiation of N-methyl-d-aspartate receptor (NMDAR) functions. We have recently shown that the activation of PAR1 either
J. S. Davies
Amino Acids, Peptides and Proteins, 29 (1998)
Thrombin induces Ca2+-dependent glutamate release from RPE cells mediated by PLC/PKC and reverse Na+/Ca2+ exchange
Lopez E, et al.
Molecular Vision (2019)
Thomas A Blair et al.
Scientific reports, 8(1), 10300-10300 (2018-07-10)
Mass cytometry (MC) uses mass spectrometry to simultaneously detect multiple metal-conjugated antibodies on single cells, thereby enabling the detailed study of cellular function. Here, for the first time, we applied MC to the analysis of platelets. We developed a panel
Shukei Sugita et al.
Micromachines, 10(2) (2019-03-03)
Some cells cultured in vitro have multiple nuclei. Since cultured cells are used in various fields of science, including tissue engineering, the nature of the multinucleated cells must be determined. However, multinucleated cells are not frequently observed. In this study

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