MAB3310
Anti-TIMP-2 Antibody, clone 67-4H11
clone 67-4H11, Chemicon®, from mouse
Synonym(s):
Tissue Inhibitor of Metalloproteinase-2
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
67-4H11, monoclonal
species reactivity
rabbit, goat, guinea pig, rat, human, bovine, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... TIMP2(7077)
Specificity
The antibody specifically reacts with human TIMP-2.
SPECIES REACTIVITY:
Cross-reacts with mouse, rat, guinea pig, rabbit and bovine TIMP-2.
SPECIES REACTIVITY:
Cross-reacts with mouse, rat, guinea pig, rabbit and bovine TIMP-2.
Immunogen
Synthetic peptide corresponding to amino acids 178-193 of human TIMP-2 (numbered from the propeptide)
YRGAAPPKQEFLDIED
YRGAAPPKQEFLDIED
Application
Anti-TIMP-2 Antibody, clone 67-4H11 detects level of TIMP-2 & has been published & validated for use in ELISA, WB, IH(P).
Immunoblotting
Immunohistochemistry on paraffin-embedded, PLP fixed tissue at 5 μg/mL (see Tomita reference) or frozen tissues at 1 μg/mL (see Ohashi reference).
ElA
Immunohistochemistry on paraffin-embedded, PLP fixed tissue at 5 μg/mL (see Tomita reference) or frozen tissues at 1 μg/mL (see Ohashi reference).
ElA
Research Category
Cell Structure
Cell Structure
Research Sub Category
MMPs & TIMPs
MMPs & TIMPs
Linkage
Replaces: MAB3356
Physical form
Format: Purified
Liquid in 0.1M Na-Phosphate buffer, pH 7.0 containing 2% protease free bovine serum albumin.
Storage and Stability
Maintain frozen at -20°C in undiluted aliquots for up to 12 months.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Manufactured by Daiichi Fine Chemical Co., Ltd
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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TNF-alpha stimulates activation of pro-MMP2 in human skin through NF-(kappa)B mediated induction of MT1-MMP.
Han, YP; Tuan, TL; Wu, H; Hughes, M; Garner, WL
Journal of Cell Science null
John Ng et al.
Investigative ophthalmology & visual science, 49(12), 5295-5306 (2008-07-22)
Ocular surface squamous neoplasia (OSSN) is an uncommon tumor of the corneal and conjunctival epithelium associated with risk of permanent visual impairment. The purposes of this study were to (1) identify and localize potential mediators in tissue from patients with
Oliver Galm et al.
Oncogene, 24(30), 4799-4805 (2005-05-05)
The tissue inhibitor of metalloproteinases-2 (TIMP-2) is known to antagonize matrix metalloproteinase activity and to suppress tumor growth, angiogenesis, invasion and metastasis. We analysed the methylation status of the CpG island in the TIMP-2 promoter region by methylation-specific polymerase chain
Wenni Tong et al.
Developmental neurobiology, 70(3), 182-194 (2009-12-18)
A recent study has shown that increased activity of matrix metalloproteinases-2 and metalloproteinases-9 (MMP-2 and MMP-9) has detrimental effect on the brain after neonatal hypoxia. The present study determined the effect of maternal hypoxia on neuronal survivability and the activity
Christina Tekle et al.
International journal of cancer, 130(10), 2282-2290 (2011-06-15)
B7-H3, an immunoregulatory protein, is known to play a role in tumor progression. In many cancer types, observed correlations between high B7-H3 expression and poor prognosis have been attributed to involvement in antitumor immunity. However, here we demonstrate a nonimmunological
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