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Muscimol hydrobromide

Name: Muscimol hydrobromide
Brand: SIGMA

≥98% (HPLC), GABAA receptor agonist, solid

Synonym(s):

5-Aminomethyl-3-hydroxyisoxazole hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₄H₆N₂O₂ · HBr

CAS Number:

18174-72-6

Molecular Weight:

195.01

UNSPSC Code:

12352200

PubChem Substance ID:

24278168

NACRES:

NA.77

MDL number:

MFCD00055184

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Product Name

Muscimol hydrobromide, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white to tan

solubility

H₂O: >10 mg/mL

storage temp.

2-8°C

SMILES string

Br[H].NCc1cc(O)no1

InChI

1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

InChI key

OPZOJWHOZRKYQX-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Description

Biochem/physiol Actions

Muscimol hydrobromide is a GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	P0618	A9111	S143
Sigma-Aldrich G019 Muscimol hydrobromide	Sigma-Aldrich P0618 cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole hydrobromide	Sigma-Aldrich A9111 (±)-AMPA hydrobromide	Sigma-Aldrich S143 (±)-6-Chloro-PB hydrobromide
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form powder	form solid
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -
solubility H₂O: >10 mg/mL	solubility H₂O: soluble ~10 mg/mL at 60 °C (Sonicate), DMSO: soluble 12 mg/mL	solubility H₂O: ≥10 mg/mL	solubility H₂O: 1.7 mg/mL, DMSO: >10 mg/mL, ethanol: 6.3 mg/mL
color off-white to tan	color light brown	color off-white to light tan	color white to light tan

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Vibrissa-based object localization in head-fixed mice.

Daniel H O'Connor et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 30(5), 1947-1967 (2010-02-05)

Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over

Compensating Level-Dependent Frequency Representation in Auditory Cortex by Synaptic Integration of Corticocortical Input.

Max F K Happel et al.

PloS one, 12(1), e0169461-e0169461 (2017-01-04)

Robust perception of auditory objects over a large range of sound intensities is a fundamental feature of the auditory system. However, firing characteristics of single neurons across the entire auditory system, like the frequency tuning, can change significantly with stimulus

Cortical State Fluctuations during Sensory Decision Making.

Elina A K Jacobs et al.

Current biology : CB, 30(24), 4944-4955 (2020-10-24)

In many behavioral tasks, cortex enters a desynchronized state where low-frequency fluctuations in population activity are suppressed. The precise behavioral correlates of desynchronization and its global organization are unclear. One hypothesis holds that desynchronization enhances stimulus coding in the relevant