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861324

Sigma-Aldrich

p-Rosolic acid

Dye content 84 %

Synonym(s):

4-[Bis(4-hydroxyphenyl)methylene]-2,5-cyclohexadienone, Aurin

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About This Item

Empirical Formula (Hill Notation):
C19H14O3
CAS Number:
603-45-2
Molecular Weight:
290.31
Colour Index Number:
43800
Beilstein:
2055205
EC Number:
210-041-8
MDL number:
MFCD00001624
UNSPSC Code:
12171500
PubChem Substance ID:
24888536
NACRES:
NA.47

form

powder

Quality Level

200

composition

Dye content, 84%

technique(s)

titration: suitable

pH

5.0-6.8, yellow to pink

cation traces

C: 66.0-90.8%

λmax

482 nm

ε (extinction coefficient)

≥11000 at 264-270 nm in ethanol
≥50000 at 478-486 nm in ethanol

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

O=C(C=C1)C=CC1=C(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3

InChI

1S/C19H14O3/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-12,20-21H

InChI key

FYEHYMARPSSOBO-UHFFFAOYSA-N

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General description

p-Rosolic acid (C.I. 43800) is an acid-baseindicator from the triphenylmethane group. It is also known as aurin and 4-[Bis(4-hydroxyphenyl)methylene]-2,5-cyclohexadienone.

Application

p-Rosolic acid has been used to induce cellular stress in HEK293 cells.

Biochem/physiol Actions

The transition range of p-Rosolic acid is around pH 6.6-8.0 (Below this pH range it is yellow and above it red).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Simultaneous detection of the subcellular localization of RNAs and proteins in cultured cells by combined multicolor RNA-FISH and IF.
Meyer C, et al.
Methods, S1046-2023 (2016)
[Not Available].
F PASCUCCI et al.
Rivista critica di clinica medica, 45(6-9), 484-493 (1945-11-30)
A Batistatou et al.
The Journal of cell biology, 122(3), 523-532 (1993-08-01)
Serum-free PC12 cell cultures have been used to study the mechanisms of neuronal death after neurotrophic factor deprivation. We previously reported that PC12 cells undergo "apoptotic" internucleosomal DNA cleavage after withdrawal of trophic support. Here, we have used a sensitive
Rakesh K Sharma et al.
Journal of medicinal chemistry, 49(12), 3595-3601 (2006-06-09)
Previously, we have reported that aurintricarboxylic acid (ATA) is one of the most potent inhibitors of the DNA binding of transcription factor NF-kappaB. We now report the NF-kappaB-DNA binding inhibitory activity of ATA analogues. An electrophoretic mobility shift assay has
W O Grabow et al.
Applied and environmental microbiology, 42(2), 192-199 (1981-08-01)
MacConkey agar, standard M-FC agar, M-FC agar without rosolic acid, M-FC agar with a resuscitation top layer, Teepol agar, and pads saturated with Teepol broth, were evaluated as growth media for membrane filtration counting of fecal coliform bacteria in water.
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