Key Documents

STAT3 Inhibitor VII

Name: STAT3 Inhibitor VII
Brand: MM

The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.

Synonym(s):

STAT3 Inhibitor VII, Ethyl-1-(4-cyano-2,3,5,6-tetrafluorophenyl)-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₇F₇N₂O₃

CAS Number:

1041438-68-9

Molecular Weight:

444.26

MDL number:

MFCD10568148

NACRES:

NA.77

UNSPSC Code:

12352200

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

Pricing and availability is not currently available.

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white to light orange

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Description

General description

A cell-permeable dihydroquinoline compound that potently and specifically inhibits cellular JAK1/JAK2/TYK2/STAT3 activation (IC₅₀ against U266 constitutive STAT3 Y705 phosphorylation =170 nM) as well as the transcription of STAT3 target genes, while exhibiting little effects against pathways involved in Akt/mTOR, Erk1/2, or STAT5 activation. Since the inhibitor does not affect JAK1/2/3 kinase activity, its cellular target(s) appears to be upstream of JAKs.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Xu, J., et al. 2008. J. Med. Chem.51, 4115.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

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This Item	573127	407625	HPA058603
Sigma-Aldrich 573103 STAT3 Inhibitor VII	Sigma-Aldrich 573127 STAT3 Inhibitor XII, SPI	Sigma-Aldrich 407625 STAT3 Inhibitor XVI	Sigma-Aldrich HPA058603 Anti-STAT3 antibody produced in rabbit
description The STAT3 Inhibitor VII, also referenced under CAS 1041438-68-9, controls the biological activity of STAT3.	description The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	description The STAT3 Inhibitor XVI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Cancer applications.	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay -
form solid	form solid	form solid	form buffered aqueous glycerol solution
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename -
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 5 mg/mL	solubility water: 100 mg/mL, DMSO: 50 mg/mL	solubility DMSO: 50 mg/mL, light pink-purple	solubility -

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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