573127
STAT3 Inhibitor XII, SPI
The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
STAT3 Inhibitor XII, SPI
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C146H238N40O42
Molecular Weight:
3225.69
UNSPSC Code:
12352200
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
desiccated (hygroscopic)
protect from light
color
white
solubility
water: 100 mg/mL
DMSO: 50 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable STAT3 SH2 domain-derived (588-615) 28-mer peptide that competitively prevents STAT3 binding to cognate pTyr peptide motif, represses STAT3 dimerization, induces apoptosis and acts as a selective constitutive STAT3 activation inhibitor in several tumor cells at 50 µM. Shown to localize in nucleus, potently block STAT3 phosphorylation, DNA-binding and transcriptional activities with minimal effect on STAT1, STAT5 and MEK signaling.
The STAT3 Inhibitor XII, SPI controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
H-Phe-Ile-Ser-Lys-Glu-Arg-Glu-Arg-Ala-Ile-Leu-Ser-Tyr-Lys-Pro-Pro-Gly-Tyr-Phe-Leu-Leu-Arg-Phe-Ser-Glu-Ser-Ser-Lys-OH
Physical form
Supplied as a trifluoroacetate salt.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Zhao, W., et al. 2010. J. Biol. Chem.285, 35855.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Inga Dunsche et al.
Human molecular genetics, 32(4), 543-550 (2022-09-02)
The signal transducer and activator of transcription 3 (STAT3) has been identified as one of the cystic fibrosis (CF) modifying genes. In this study, we aimed to assess the association between STAT3 genotype and CF patient survival over several decades
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service