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P0175

Sigma-Aldrich

pGlu-Val-Asn-Phe-Ser-Pro-Gly-Trp-Gly-Thr-NH2

≥95% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C50H67N13O14
CAS Number:
106018-36-4
Molecular Weight:
1074.15
MDL number:
MFCD00076638
UNSPSC Code:
12352202
PubChem Substance ID:
24898082
NACRES:
NA.26

Product Name

pGlu-Val-Asn-Phe-Ser-Pro-Gly-Trp-Gly-Thr-NH2, ≥95% (HPLC)

Assay

≥95% (HPLC)

form

powder

color

white to off-white

storage temp.

−20°C

SMILES string

CC(C)C(NC(=O)C1CCC(=O)N1)C(=O)NC(CC(N)=O)C(=O)NC(Cc2ccccc2)C(=O)NC(CO)C(=O)N3CCCC3C(=O)NCC(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NCC(=O)NC(C(C)O)C(N)=O

InChI

1S/C50H67N13O14/c1-25(2)41(62-45(72)31-15-16-38(67)56-31)49(76)59-34(20-37(51)66)47(74)58-32(18-27-10-5-4-6-11-27)46(73)60-35(24-64)50(77)63-17-9-14-36(63)48(75)55-22-39(68)57-33(19-28-21-53-30-13-8-7-12-29(28)30)44(71)54-23-40(69)61-42(26(3)65)43(52)70/h4-8,10-13,21,25-26,31-36,41-42,53,64-65H,9,14-20,22-24H2,1-3H3,(H2,51,66)(H2,52,70)(H,54,71)(H,55,75)(H,56,67)(H,57,68)(H,58,74)(H,59,76)(H,60,73)(H,61,69)(H,62,72)

InChI key

NHXHBXCOYZFUSO-UHFFFAOYSA-N

Amino Acid Sequence

Glp-Val-Asn-Phe-Ser-Pro-Gly-Trp-Gly-Thr-NH2

Biochem/physiol Actions

Hypertrehalosemic neuropeptide from cockroach (Nauphoeta cinerea) with an amino acid sequence similar to that of adipokinetic hormone; involved in carbohydrate metabolism and increases the trehalose content of hemolymph.
Glp-Val-Asn-Phe-Ser-Pro-Gly-Trp-Gly-Thr-NH2 is a hypertrehalosemic neuropeptide (Nauphoeta cinerea) has an amino acid sequence similar to that of adipokinetic hormone and is involved in carbohydrate metabolism and increases the trehalose content of hemolymph.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCP7703
SLCN3738
110M1252V
110M1252
030M1563

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J Kim et al.
Biochemistry and molecular biology international, 35(4), 803-811 (1995-04-01)
A new method for the determination of the modified amino acid structures of peptides containing pyroglutamyl residue in their N-terminal position is reported. The combination of fast atom bombardment (FAB) mass spectrometry and pyroglutamate aminopeptidase digestion provides a convenient and
T R Davenport et al.
Parasitology, 108 ( Pt 4), 479-485 (1994-05-01)
Evidence for the presence of adipokinetic hormone/hypertrehalosaemic hormone (AKH/HrTH)-like peptides in the parasitic nematodes Ascaridia galli and Ascaris suum has been obtained using insect bioassays which measure hyperglycaemic responses to peptides belonging to the AKH/HrTH family of insect hormones. A
G Gäde et al.
General and comparative endocrinology, 86(1), 119-127 (1992-04-01)
Two hypertrehalosemic neuropeptides from the corpus cardiacum of the cockroach Polyphaga aegyptiaca were isolated by reversed-phase high-performance liquid chromatography, and their primary structures were determined by pulsed-liquid phase sequencing employing Edman chemistry, after enzymically deblocking the N-terminal pyroglutamate residue. As
J Y Bradfield et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(10), 4558-4562 (1991-05-15)
Hypertrehalosemic hormone (a carbohydrate-mobilizing neuroendocrine decapeptide) and starvation markedly increased levels of a cockroach (Blaberus discoidalis) fat body cytochrome P450 message. The gene represented by the cloned P450 cDNA has been named CYP4C1 (cytochrome P450 family 4, subfamily C, gene
G Gäde et al.
Biochemical and biophysical research communications, 141(2), 774-781 (1986-12-15)
The hypertrehalosaemic factor from the cockroach Nauphoeta cinerea, a decapeptide, has been assigned the structure >Glu-Val-Asn-Phe-Ser-Pro-Gly-Trp-Gly-Thr-NH2. The structure was assigned from its high-resolution fast atom bombardment mass spectrum and metastable studies on the M + H ion and confirmed by
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