579602
(R)-(+)-1,2-Dithiolane-3-pentanoic acid
97%
Synonym(s):
(R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid
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About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
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Assay
97%
form
solid
optical activity
[α]20/D +104°, c = 1 in chloroform
mp
48-52 °C (lit.)
SMILES string
OC(=O)CCCC[C@@H]1CCSS1
InChI
1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
InChI key
AGBQKNBQESQNJD-SSDOTTSWSA-N
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Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Michela Rosini et al.
Journal of medicinal chemistry, 48(2), 360-363 (2005-01-22)
The coupling of two different pharmacophores, each endowed with different biological properties, afforded the hybrid compound lipocrine (7), whose biological profile was markedly improved relative to those of prototypes tacrine and lipoic acid. Lipocrine is the first compound that inhibits
Alessandra Antonello et al.
Journal of medicinal chemistry, 48(1), 28-31 (2005-01-07)
To combine in the same molecule alpha(1)-adrenoreceptor blocking and antioxidant properties, compounds 2-5 were designed and synthesized. All compounds were effective alpha(1)-adrenoreceptor antagonists and were tested in both functional and binding assays. In addition, compounds 2 and 5 also displayed
Daniel Konrad
Antioxidants & redox signaling, 7(7-8), 1032-1039 (2005-07-07)
Alpha-lipoic acid is a naturally occurring cofactor of mitochondrial dehydrogenase complexes and a potent antioxidant. It can interchange between a reduced form and an oxidized form, thereby displaying reducing (antioxidant) and prooxidant properties, respectively. It is suggested that alpha-lipoic acid
Sylvaine F A Bruggraber et al.
Gastroenterology, 125(6), 1705-1713 (2004-01-16)
Although considerable effort has been directed toward the mapping of peptide epitopes by autoantibodies, the role of nonprotein molecules has been less well studied. The immunodominant autoantigen in primary biliary cirrhosis (PBC), E2 components of pyruvate dehydrogenase complexes (PDC-E2), has
B Steinmann et al.
Helvetica paediatrica acta, 34(6), 589-599 (1979-01-01)
Strychnine, a potent antagonist of glycine was given to twins suffering from nonketotic hyperglycinemia at age 73 hours. Within hours of the onset of treatment favorable effects were observed such as improvements of muscle tone, movements, defense reactions, and probably
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