421235
1-(2-Pyrimidyl)piperazine
98%
Synonym(s):
2-(1-Piperazinyl)pyrimidine
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Empirical Formula (Hill Notation):
C8H12N4
Molecular Weight:
164.21
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Pricing and availability is not currently available.
Recommended Products
Assay
98%
refractive index
n20/D 1.587 (lit.)
bp
277 °C (lit.)
density
1.158 g/mL at 25 °C (lit.)
SMILES string
C1CN(CCN1)c2ncccn2
InChI
1S/C8H12N4/c1-2-10-8(11-3-1)12-6-4-9-5-7-12/h1-3,9H,4-7H2
InChI key
MRBFGEHILMYPTF-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
General description
Application
1-(2-Pyrimidyl)piperazine may be used for the following studies:
- As derivatization reagent for the carboxyl groups on peptides.[1]
- Carboxy group derivatization during the spectrophotometric analysis of phosphopeptides.[3]
- Starting reagent for the synthesis of 3-{(4-(pyrimidin-2-yl)piperazin-1-yl)methyl}-1H-pyrrolo[2,3-b]pyridine.[4]
- Synthesis of 3-phenyl-6-(4-(pyrimidin-2-yl)piperazin-1-yl)pyridazin-4-ol.[5]
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
>230.0 °F
Flash Point(C)
> 110 °C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
A Gobert et al.
Neuroscience, 93(4), 1251-1262 (1999-09-29)
The serotonin1A receptor partial agonist, buspirone, also displays antagonist properties at D2 receptors and is metabolized to the alpha2-adrenergic receptor antagonist, 1-(2-pyrimidinyl-piperazine). Herein, we examined mechanisms underlying the influence of buspirone alone, and in association with the serotonin reuptake inhibitor
B J Cao et al.
Neuropharmacology, 36(8), 1089-1097 (1997-08-01)
It has been suggested that in vivo formation of the metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) may be a major drawback in the use of buspirone as an anti-anxiety agent. To test this hypothesis, the effects of buspirone, alone or with proadifen (an
I Mahmood et al.
Clinical pharmacokinetics, 36(4), 277-287 (1999-05-13)
Buspirone is an anxiolytic drug given at a dosage of 15 mg/day. The mechanism of action of the drug is not well characterised, but it may exert its effect by acting on the dopaminergic system in the central nervous system
K T Kivistö et al.
Therapeutic drug monitoring, 21(3), 317-321 (1999-06-12)
Two separate gas chromatographic methods for the determination of buspirone and its active metabolite, 1-(2-pyrimidinyl)-piperazine (1-PP) in human plasma are described. Both procedures involve solid-phase extraction (the packing material of the cartridges used was C8 for buspirone and a mixed-mode
A H Vaidya et al.
Methods and findings in experimental and clinical pharmacology, 27(4), 245-255 (2005-08-06)
Most studies concerning the effects of oral buspirone in the rat elevated plus-maze (EPM) test, spontaneous motor activity (SMA) test, and Vogel conflict (VC) test have used Sprague-Dawley or Wistar rats. Although it has been documented that the behavior of
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
