T7665

Tyrphostin 51

≥98%

• Synonym(s): 2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
• Empirical Formula (Hill Notation): C₁₃H₈N₄O₃
• CAS Number: 126433-07-6
• Molecular Weight: 268.23
• MDL number: MFCD00133903
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278756
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 200
• Assay: ≥98%
• form: powder
• potency: 0.8 μM IC₅₀
• solubility: DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
• storage temp.: 2-8°C
• SMILES string: NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
• InChI: 1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
• InChI key: JKNOYWVMHPMBEL-UNXLUWIOSA-N
• Gene Information: human ... CDK2(1017) , EGFR(1956)

Description

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.

Biochem/physiol Actions

Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

EGFR tyrosine kinase inhibitor.

Features and Benefits

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Preparation Note

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves