T7165

Tyrphostin 23

≥98%

• Synonym(s): (3,4-Dihydroxybenzylidene)malononitrile, RG-50810
• Empirical Formula (Hill Notation): C₁₀H₆N₂O₂
• CAS Number: 118409-57-7
• Molecular Weight: 186.17
• MDL number: MFCD00133899
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278041
• NACRES: NA.77

Properties

• biological source: synthetic (organic)
• Quality Level: 100
• Assay: ≥98%
• form: powder
• potency: 35 μM IC₅₀
• solubility: DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
• storage temp.: 2-8°C
• SMILES string: Oc1ccc(cc1O)\C=C(\C#N)C#N
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• InChI key: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Gene Information: human ... CDK2(1017)

Description

Application

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Biochem/physiol Actions

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves