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880224P

Avanti

DSPE-PEG(5000) Maleimide

Avanti Research™ - A Croda Brand 880224P, powder

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-5000] (ammonium salt)

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About This Item

CAS Number:
474922-22-0
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 5 mg (880224P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880224P

shipped in

dry ice

storage temp.

−20°C

SMILES string

O=C(CCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCC)=O)([H])COP([O-])(OCCNC([(OCH2CH2)113]NC(CCN1C(C=CC1=O)=O)=O)=O)=O.[NH4+]

Application

DSPE-PEG(5000) maleimide is suitable for the preparation of cationic liposomes for loading siRNA.. It has also been conjugated with Asn-Gly-Arg to prepare NLC (nanostructured lipid carrier).

Biochem/physiol Actions

Maleimide are useful in biomolecular conjugation. DSPE-PEG(5000) maleimide is used to prepare conjugated polymer nanoparticles.

Packaging

5 mL Amber Glass Screw Cap Vial (880224P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Catalysis of imido-group hydrolysis in a maleimide conjugate
Kalia J and Raines RT
Bioorganic & Medicinal Chemistry Letters, 17, 6286?6289-6286?6289 (2007)
Conjugated Polymers for Biological and Biomedical Applications, 29-29 (2018)
Yang Yang et al.
Biomaterials, 48, 84-96 (2015-02-24)
Tumor-oriented nanocarrier drug delivery approaches with photosensitivity have drawn considerable attention over the years. However, due to its low penetrability and ability to harm tissues, the use of UV light for triggered nanocarrier release in in vivo applications has been
Yanfang Yang et al.
Journal of pharmaceutical sciences, 104(4), 1328-1339 (2015-01-30)
A novel nanostructured lipid carrier (NLC) modified with photon-sensitive cell penetrating peptides (psCPP) and Asn-Gly-Arg (NGR) was designed to enhance paclitaxel (PTX)-targeted delivery and antitumor effect. The NGR moiety selectively binds to CD13-positive tumors. On other hand, the psCPP moiety

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