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Key Documents

880120P

Avanti

18:0 PEG2000 PE

Avanti Research - A Croda Brand

Synonym(s):

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 g (880120P-1g)
pkg of 1 × 200 mg (880120P-200mg)
pkg of 1 × 25 mg (880120P-25mg)
pkg of 1 × 500 mg (880120P-500mg)

manufacturer/tradename

Avanti Research - A Croda Brand

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[NH4+]

General description

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is conjugate, covalently attached to polyethylene glycol (PEG2000). It forms a stable micelle of 180kDa with phosphoethanolamine as hydrophobic core and hydrophilic PEG2000 as outer micelle surface.

Application

18:0 PEG2000 PE may be used in the nickel resin functionalization of quantum dots. It may also be used in liposome preparation.

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000 (18:0 PEG2000 PE) is an effective drug carrier and is biocompatible. PEG stabilizes and protects the micelle from phagocytic system. The use of PEG as a conjugate with phospholipids enables improved liposome preparation and effective drug encapsulation.

Packaging

20 mL Clear Glass Screw Cap Vial (880120P-1g)
20 mL Clear Glass Screw Cap Vial (880120P-500mg)
5 mL Amber Glass Screw Cap Vial (880120P-200mg)
5 mL Amber Glass Screw Cap Vial (880120P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

also commonly purchased with this product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


Certificates of Analysis (COA)

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Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes
Graham SM, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 178, 101-107 (2014)
Structure and dynamics of highly PEG-ylated sterically stabilized micelles in aqueous media
Vukovic L, et al.
Journal of the American Chemical Society, 133(34), 13481-13488 (2011)
Relationship between targeting efficacy of liposomes and the dosage of targeting antibody using surface plasmon resonance
Xiang Y, et al.
Langmuir, 31(44), 12177-12186 (2015)
P A Melnikov et al.
Bulletin of experimental biology and medicine (2019-11-24)
We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the
Kathleen Cullion et al.
Pharmaceutical research, 36(12), 179-179 (2019-11-11)
It is unknown whether there are sex differences in response to free or encapsulated local anesthetics. We examined nerve block duration and toxicity following peripheral nerve blockade in male and female rats. We studied the local anesthetic bupivacaine (free or

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