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P3531

Sigma-Aldrich

1,2-Distearoyl-sn-glycero-3-phosphoethanolamine

≥99%

Synonym(s):

1,2-Dioctadecanoyl-sn-glycero-3-phosphoethanolamine, 3-sn-Phosphatidylethanolamine, 1,2-distearoyl, L-β,γ-Distearoyl-α-cephalin

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About This Item

Empirical Formula (Hill Notation):
C41H82NO8P
CAS Number:
1069-79-0
Molecular Weight:
748.07
Beilstein:
1730641
EC Number:
213-963-9
MDL number:
MFCD00036777
UNSPSC Code:
12352207
PubChem Substance ID:
24898422
NACRES:
NA.77

Quality Level

100

Assay

≥99%

form

powder

lipid type

phospholipids

storage temp.

−20°C

SMILES string

CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCCN)OC(=O)CCCCCCCCCCCCCCCCC

InChI

1S/C41H82NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h39H,3-38,42H2,1-2H3,(H,45,46)/t39-/m1/s1

InChI key

LVNGJLRDBYCPGB-LDLOPFEMSA-N

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Application


  • Injectable Composite Hydrogels Embedded with Gallium-Based Liquid Metal Particles for Solid Breast Cancer Treatment via Chemo-Photothermal Combination.: This article presents the use of DSPE in developing injectable composite hydrogels. These hydrogels are embedded with liquid metal particles to provide a dual-mode treatment approach combining chemotherapy and photothermal therapy for breast cancer (Lee et al., 2024).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yi-Ping Fang et al.
International journal of nanomedicine, 13, 2789-2802 (2018-05-23)
SN38 (7-ethyl-10-hydroxycamptothecin) is a camptothecin derivative acts against various tumors. However, SN38 is hydrolyzed in the physiological environment (pH 7.4), and this instability interferes with its potential therapeutic effect. Our objective was to investigate SN38-loaded liposomes to overcome the poor
Josanne Sophia de Maar et al.
Theranostics, 10(4), 1884-1909 (2020-02-12)
Genetic and phenotypic tumour heterogeneity is an important cause of therapy resistance. Moreover, non-uniform spatial drug distribution in cancer treatment may cause pseudo-resistance, meaning that a treatment is ineffective because the drug does not reach its target at sufficient concentrations.
Yegor A Domanov et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(31), 12605-12610 (2011-07-20)
Lipid and protein lateral mobility is essential for biological function. Our theoretical understanding of this mobility can be traced to the seminal work of Saffman and Delbrück, who predicted a logarithmic dependence of the protein diffusion coefficient (i) on the
Marissa A Tafoya et al.
Journal of magnetic resonance imaging : JMRI, 46(2), 574-588 (2016-11-23)
To optimize magnetic resonance imaging (MRI) of antibody-conjugated superparamagnetic nanoparticles for detecting amyloid-β plaques and activated microglia in a 3X transgenic mouse model of Alzheimer's disease. Ten 3X Tg mice were fed either chow or chow containing 100 ppm resveratrol. Four
Hong Wu et al.
Biomaterials, 34(4), 1213-1222 (2012-10-30)
To introduce pH sensitivity into the DSPE-PEG-based micellar system and achieve the quick intracellular drug release in response to the acidity in endosomes, a mixed polymeric micelle was developed based on three grafted copolymers, including 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-2000(DSPE-PEG(2000)), antinucleosome antibody (mAb
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