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H6377

Sigma-Aldrich

1-Hydroxypyridine-2-thione zinc salt

≥95%

Synonym(s):

Mercaptopyridine N-oxide zinc salt, Pyrithione

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About This Item

Empirical Formula (Hill Notation):
C10H8N2O2S2Zn
CAS Number:
13463-41-7
Molecular Weight:
317.70
EC Number:
236-671-3
MDL number:
MFCD00067336
UNSPSC Code:
12352100
PubChem Substance ID:
57654263
NACRES:
NA.22

Quality Level

100

Assay

≥95%

SMILES string

O1N2C=CC=CC2=[S][Zn]13ON4C=CC=CC4=[S]3

InChI

1S/2C5H5NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4,8H;/q;;+2/p-2

InChI key

OTPSWLRZXRHDNX-UHFFFAOYSA-L

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Application


  • Antimicrobial nanocoatings: The compound 1-Hydroxypyridine-2-thione zinc salt was evaluated for its efficacy in antimicrobial nanocoatings, showcasing its role in enhancing the performance of such coatings used in healthcare and industrial environments to prevent microbial contamination (Molling et al., 2014).

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Repr. 1B - STOT RE 1

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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M Tailler et al.
Oncogene, 31(30), 3536-3546 (2011-11-23)
Despite recent progress in the treatment of acute myeloid leukemia (AML), the prognosis of this rather heterogeneous disease remains poor and novel chemotherapeutics that specifically target leukemic cells must be developed. To address this need at the preclinical level, we
Michael G Leitner et al.
British journal of pharmacology, 165(7), 2244-2259 (2011-09-29)
DFNA2 is a frequent hereditary hearing disorder caused by loss-of-function mutations in the voltage-gated potassium channel KCNQ4 (Kv7.4). KCNQ4 mediates the predominant K(+) conductance, I(K,n) , of auditory outer hair cells (OHCs), and loss of KCNQ4 function leads to degeneration
Tomohiro M Oyama et al.
Chemosphere, 87(11), 1316-1322 (2012-02-24)
Zinc pyrithione is used as an antifouling agent. However, the environmental impacts of zinc pyrithione have recently been of concern. Zinc induces diverse actions during oxidative stress; therefore, we examined the effect of zinc pyrithione on rat thymocytes suffering from
Kathy Kerr et al.
International journal of dermatology, 50(1), 102-113 (2010-12-25)
Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. These symptoms reflect underlying histopathologic and biochemical events that must be reversed if treatment is to be effective. This study aimed to better characterize the state
Viswanath Kasi et al.
Biochemical and biophysical research communications, 410(2), 270-275 (2011-06-10)
Zinc pyrithione (ZPT), has a strong anti-apoptotic effect when administered just before reperfusion. Because oxidative stress has been proposed to contribute to myocardial reperfusion injury, we tested whether ZPT can reduce the production of reactive oxygen species during reoxygenation in
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