764752
Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA Mn 55,000
Synonym(s):
PEG-PLGA, Polyethylene glycol, mPEG-b-PLGA, mPEG-b-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
UNSPSC Code:
12162002
NACRES:
NA.23
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description
typical PEG PDI < 1.1; overall PDI < 2.5
Quality Level
form
pellets
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000
PLGA Mn 55,000
average Mn 60,000 (total)
degradation timeframe
1-4 weeks
transition temp
Tg 10 °C(lit.)
Tm 254-259 °C
PDI
<1.2
storage temp.
2-8°C
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General description
Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part.
Application
Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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