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442687

Supelco

N-Nitrosodiethylamine

analytical standard

Sinónimos:

Diethylnitrosamine

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About This Item

Fórmula lineal:
(C2H5)2NNO
Número de CAS:
55-18-5
Peso molecular:
102.14
Beilstein:
1744991
Número CE:
200-226-1
Número MDL:
MFCD00013890
Código UNSPSC:
12000000
ID de la sustancia en PubChem:
24867961

grado

analytical standard

CofA

current certificate can be downloaded

envase

ampule of 1000 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

bp

177 °C (lit.)

densidad

0.95 g/mL (lit.)

aplicaciones

cleaning products
cosmetics
environmental
food and beverages
personal care

Formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

CCN(CC)N=O

InChI

1S/C4H10N2O/c1-3-6(4-2)5-7/h3-4H2,1-2H3

Clave InChI

WBNQDOYYEUMPFS-UHFFFAOYSA-N

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Aplicación

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palabra de señalización

Danger

Frases de peligro

H301,H350,H412

Clasificaciones de peligro

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 1B

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
LC19889V
LC05526V
LC04672V
LB99175V
LB99174V

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Visite la Librería de documentos

L Verna et al.
Pharmacology & therapeutics, 71(1-2), 57-81 (1996-01-01)
N-Nitrosodiethylamine (NDEA) is DNA reactive after bioactivation and produces tumors in every animal species tested. Bioactivation is effected by several P450 isozymes including CYP2E1, which is ethanol inducible. Tumor formation in rat liver was proportional to O4-ethyldeoxythymidine formation in DNA
Takeki Uehara et al.
Toxicological sciences : an official journal of the Society of Toxicology, 132(1), 53-63 (2013-01-05)
Hepatocellular carcinoma (HCC) mostly develops in patients with advanced fibrosis; however, the mechanisms of interaction between a genotoxic insult and fibrogenesis are not well understood. This study tested a hypothesis that fibrosis promotes HCC via a mechanism that involves activation
Marta Anna Kowalik et al.
Oncotarget, 6(36), 38749-38763 (2015-10-10)
Although the expression of the stem/progenitor cell marker cytokeratin-19 (CK-19) has been associated with the worst clinical prognosis among all HCC subclasses, it is yet unknown whether its presence in HCC is the result of clonal expansion of hepatic progenitor
Masaaki Miyakoshi et al.
Molecular carcinogenesis, 53(1), 67-76 (2012-08-23)
STAT3 activation is involved in development and progression of hepatocellular carcinoma (HCC). We investigated STAT3 activation during hepatocarcinogenesis induced by neonatal diethylnitrosamine (DEN) treatment in mice. Nuclear accumulation and phosphorylation of STAT3 were detected in altered hepatocyte foci in the
Esther Bertran et al.
Hepatology (Baltimore, Md.), 58(6), 2032-2044 (2013-07-03)
Transforming growth factor-beta (TGF-β) is an important regulatory suppressor factor in hepatocytes. However, liver tumor cells develop mechanisms to overcome its suppressor effects and respond to this cytokine by inducing other processes, such as the epithelial-mesenchymal transition (EMT), which contributes
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