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Merck
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Key Documents

SML2899

Sigma-Aldrich

Humanin Trifluoroacetate

≥95% (HPLC)

Sinónimos:

L-Methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonyl-L-seryl-L-?-glutamyl-L-isoleucyl-L-?-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-L-alanine trifluoroacetate, MAPRGFSCLLLLTSEIDLPVKRRA trifluoroacetate, Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

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About This Item

Fórmula empírica (notación de Hill):
C119H204N34O32S2 · xC2HF3O2
Peso molecular:
2687.23 (free base basis)
UNSPSC Code:
12352202
NACRES:
NA.77

Quality Level

100

assay

≥95% (HPLC)

form

lyophilized powder

color

white to beige

storage temp.

−20°C

Biochem/physiol Actions

Humanin is 24-amino acid mitochondria-associated peptide that is involved in numerous biological processes including apoptosis, cell survival, substrate metabolism, inflammatory response, and response to stressors such as oxidative stress, ischemia, and starvation. Humanin exhibits protective effects against cellular apoptosis. Apparently it inhibits BAX translocation to the mitochondrial outer membrane.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sandra Cristina Zárate et al.
Frontiers in aging neuroscience, 11, 123-123 (2019-06-20)
Astroglial cells are crucial for central nervous system (CNS) homeostasis. They undergo complex morpho-functional changes during aging and in response to hormonal milieu. Ovarian hormones positively affect different astroglia parameters, including regulation of cell morphology and release of neurotrophic and
Daniel L Morris et al.
The Journal of biological chemistry, 294(50), 19055-19065 (2019-11-07)
The mitochondrial, or intrinsic, apoptosis pathway is regulated mainly by members of the B-cell lymphoma 2 (BCL-2) protein family. BCL-2-associated X apoptosis regulator (BAX) plays a pivotal role in the initiation of mitochondria-mediated apoptosis as one of the factors causing
Y Hashimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(11), 6336-6341 (2001-05-24)
Through functional expression screening, we identified a gene, designated Humanin (HN) cDNA, which encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimer's disease genes and by Abeta amyloid, without effect on

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