SML1467

ASP7663

≥98% (HPLC)

• Sinónimos: (2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid, (E)-[7-Fluoro-1-(2-methylpropyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]acetic acid
• Fórmula empírica (notación de Hill): C₁₄H₁₄FNO₃
• Número de CAS: 1190217-35-6
• Peso molecular: 263.26
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825901
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: light orange to dark orange
• solubilidad: DMSO: 25 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(C)CN(C1=C(F)C=CC=C1/C2=C\C(O)=O)C2=O
• InChI: 1S/C14H14FNO3/c1-8(2)7-16-13-9(4-3-5-11(13)15)10(14(16)19)6-12(17)18/h3-6,8H,7H2,1-2H3,(H,17,18)/b10-6+
• Clave InChI: RCVZUIGCNAAMIC-UXBLZVDNSA-N

Descripción

Acciones bioquímicas o fisiológicas

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1), known to play a role for chemical sensing in the pain pathway. ASP7663 activated human, rat, and mouse TRPA1 receptors with EC₅₀ values of 510, 540, and 500 nM, respectively, and little or no affinity at more than 60 other related receptors, channels and enzymes. ASP7663 enhanced colonic motility and exerted analgesic effects against abdominal pain in mouse models.

ASP7663 is a selective activator of transient receptor potential ankyrin 1 (TRPA1).

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable