I4883

Ibuprofen

≥98% (GC), powder, COX inhibitor

• Sinónimos: 2-(4-Isobutylphenyl)propanoic acid, Brufen, Motrin, Rebugen, α-Methyl-4-(isobutyl)phenylacetic acid, (±)-2-(4-Isobutylphenyl)propanoic acid
• Fórmula empírica (notación de Hill): C₁₃H₁₈O₂
• Número de CAS: 15687-27-1
• Peso molecular: 206.28
• EC Number: 239-784-6
• MDL number: MFCD00010393
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277715
• NACRES: NA.77

Propiedades

• product name: Ibuprofen, ≥98% (GC)
• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥98% (GC)
• form: powder
• mp: 77-78 °C
• solubility: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• SMILES string: CC(C)Cc1ccc(cc1)C(C)C(O)=O
• InChI: 1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
• InChI key: HEFNNWSXXWATRW-UHFFFAOYSA-N
• Gene Information: human ... ALB(213) , ALOX5(240) , CYP1A2(1544) , CYP2C9(1559) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743) ; mouse ... Alox5(11689) ; rat ... Alox5(25290) , Ptgs1(24693)

Descripción

General description

Ibuprofen is a commonly used nonsteroidal anti-inflammatory drug (NSAID) known for its pain-relieving, anti-inflammatory, and fever-reducing properties. It can hinder the effectiveness of various antihypertensive medications, including β-adrenergic blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, and diuretics. Ibuprofen exists in an unbound state in cerebrospinal fluid and is accumulated in the synovial fluid of inflamed joints in arthritis patients.

Application

Ibuprofen has been used:

• to study its vascular and pulmonary effects on neonatal lung development
• to study its effects on cell apoptosis, cell proliferation, and histology changes in human cholangiocarcinoma cell lines
• in the preparation of a terpene-based therapeutic deep eutectic system (THEDES) to investigate its physicochemical, antimicrobial, and anticancer properties

Biochem/physiol Actions

Cyclooxygenase (COX) inhibitor that has greater activity against COX-1 than against COX-2.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P301 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves