P4404
Polyguanylic acid potassium salt
lyophilized powder
Sinónimos:
Poly(G) potassium salt
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About This Item
Productos recomendados
origen biológico
enzyme from (synthesis)
Nivel de calidad
Ensayo
≥95% (TLC)
Formulario
lyophilized powder
calidad
≤5% free nucleotides
solubilidad
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow
temp. de almacenamiento
−20°C
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Descripción general
Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase.
Aplicación
Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine.
Polyguanylic acid potassium salt has been used:
- as a ligand for surface neuropilin-1 (NRP1) for internalization studies
- for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method
- as a synthetic polynucleotide for agarose gel electrophoresis analysis
Acciones bioquímicas o fisiológicas
Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.
Nota de preparación
Prepared from GDP using polynucleotide phosphorylase
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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The redox mechanism of two trisubstituted triazole-linked phenyl derivatives (CL41 and CL42) and a disubstituted triazole-linked phenyl derivative (CL2r50) were studied using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The CL41, CL42 and CL2r50 oxidation
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