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P4404

Sigma-Aldrich

Polyguanylic acid potassium salt

lyophilized powder

Sinónimos:

Poly(G) potassium salt

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About This Item

Número de CAS:
54684-83-2
Número MDL:
MFCD00131976
Código UNSPSC:
41106305
NACRES:
NA.51

origen biológico

enzyme from (synthesis)

Nivel de calidad

200

Ensayo

≥95% (TLC)

Formulario

lyophilized powder

calidad

≤5% free nucleotides

solubilidad

water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow

temp. de almacenamiento

−20°C

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Descripción general

Polyguanylic acid takes up a four-stranded helical structure. It is synthetically produced in Thermus thermophilus from guanosine diphosphate (GDP) and its synthesis is catalyzed by the enzyme polynucleotide phosphorylase.

Aplicación

Polyguanylic acid (PolyG) is used to study the effects of ionizing radiation on formation and stability of G-quadruplex structures and as a target molecule for physicochemical studies of electronic excitation (vibrational spectra) of guanosine.
Polyguanylic acid potassium salt has been used:
  • as a ligand for surface neuropilin-1 (NRP1) for internalization studies
  • for intercalation studies with trisubstituted and disubstituted triazole-linked phenyl derivatives CL41, CL42 and CL2r50 using voltammetry method
  • as a synthetic polynucleotide for agarose gel electrophoresis analysis

Acciones bioquímicas o fisiológicas

Polyguanylic acid acts as a ligand for scavenger receptor and reduces the surface expression neuropilin-1 in endothelial cells.

Nota de preparación

Prepared from GDP using polynucleotide phosphorylase

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000367635
0000367635
0000314987
0000314988
12180908

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Nathan R Deleault et al.
The Journal of biological chemistry, 280(29), 26873-26879 (2005-05-27)
Little is currently known about the biochemical mechanism by which induced prion protein (PrP) conformational change occurs during mammalian prion propagation. In this study, we describe the reconstitution of PrPres amplification in vitro using partially purified and synthetic components. Overnight
Masashi Narazaki et al.
Blood, 116(16), 3099-3107 (2010-07-08)
Ligand interaction with cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonged or excessive signaling from extracellular ligands. Compounds that induce internalization of surface receptors prevent ligand binding to cognate cell-surface receptors serving as inhibitors. Here, we show
Picosecond infrared probing of the vibrational spectra of transients formed upon UV excitation of stacked G-tetrad structures.
McGovern DA, Quinn S, Doorley GW, et al.
Chemical Communications (Cambridge, England), 28, 5158-5160 (2007)
D Grygoryev et al.
Radiation research, 173(1), 110-118 (2010-01-01)
The ability of guanine-rich sequences to form quadruplex structures in telomeres for example is important in a number of biological processes such as aging, carcinogenesis and gene regulation. Ionizing radiation can cause damage to guanine moieties that can affect the
A study of the pH dependence of electronically excited guanosine compounds by picosecond time-resolved infrared spectroscopy.
McGovern DA, Doorley GW, et al.
Photochemistry and Photobiology, 8, 542-548 (2008)
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