N2513
Nerve Growth Factor β rat
≥97% (SDS-PAGE), recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture
Sinónimos:
NGF-β from rat, Nerve Growth Factor-β from rat
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About This Item
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Nombre del producto
NGF-β from rat, recombinant, expressed in Sf21 cells, lyophilized powder, suitable for cell culture
origen biológico
rat
Nivel de calidad
recombinante
expressed in Sf21 cells
Ensayo
≥97% (SDS-PAGE)
Formulario
lyophilized powder
potencia
0.15-3.00 ng/mL EC50
envase
pkg of 0.1 mg
técnicas
cell culture | mammalian: suitable
impurezas
endotoxin, tested
solubilidad
water: soluble 0.1 g/L at 20 °C
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
rat ... NGF(4803)
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Descripción general
NGFβ (nerve growth factor β) is a protein involved in signal transduction, and expressed by multiple tissues such as placenta, urothelium and bladder smooth muscle cells. It is a neurotrophin and belongs to the NGF family.
Aplicación
NGF-β from rat is used for the following applications:
- In the preparation of DMEM medium (for the cultivation and differentiation of PC12 cells)
- Western blotting analysis
- For the preparation of differentiation medium (it is prepared from DMEM, in which NGF-β is one of the components)
- In cell culture and treatment (for neuronal differentiation)
- In the preparation of stock solution
Acciones bioquímicas o fisiológicas
NGFβ (nerve growth factor β) is essential for the differentiation and survival of neurons. It also plays a key role in the development and maintenance of nervous system. It is also involved in angiogenesis, and facilitates tumorigenesis such as, oral, breast and prostate cancers. It has potential as marker for the diagnosis of interstitial cystitis/painful bladder syndrome (IC/PBS) and overactive bladder (OAB), and might also aid in determining the therapy for the same. It might be involved in changes in placental function, as NGF signaling is influenced by antenatal depression and selective serotonin reuptake inhibitor (SSRI) treatment.
Forma física
Lyophilized from a 0.2 μm filtered solution in PBS and 1 M NaCl containing 50 μg of bovine serum albumin per 1 μg of cytokine
Nota de análisis
The biological activity is measured in a cell proliferation assay using the factor-dependent human erythroleukemic cell line, TF-1.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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