I9409
Monoclonal Anti-Insulin-like Growth Factor-I antibody produced in hamster
clone 126002, purified immunoglobulin, lyophilized powder
Sinónimos:
Anti-IGF-I
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About This Item
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Productos recomendados
origen biológico
hamster
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
126002, monoclonal
Formulario
lyophilized powder
reactividad de especies
mouse
técnicas
capture ELISA: 2-8 μg/mL
neutralization: suitable
western blot: 1-2 μg/mL
isotipo
IgG1
Nº de acceso UniProt
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
mouse ... Igf1(16000)
Descripción general
Insulin-like Growth Factor-I (also known as somatomedinC and somatomedin A) and insulin-like growth factor-II(IGF-II) belong to the family of insulin-like growthfactors, which are structurally homologous to proinsulin.Mature IGF-I and IGF-II are h
Inmunógeno
purified, E. coli-derived recombinant mouse insulin-like growth factor-I.
Acciones bioquímicas o fisiológicas
Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades. The effects of IGF-1R signaling are important at many developmental levels from cells to organ to organism, growth, differentiation, anti-apoptosis, proliferation and transformation.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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J Dupont et al.
Hormone research, 55 Suppl 2, 22-26 (2001-10-31)
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) belong to the same subfamily of receptor tyrosine kinases with two extracellular alpha-subunits and two transmembrane beta-subunits. They share a high similarity of structure and intracellular signalling events.
C J Rosen
Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)
The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated
Ettore Capoluongo
The American journal of pathology, 178(1), 26-31 (2011-01-13)
Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF
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