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A2093

Sigma-Aldrich

Aspirin

meets USP testing specifications

Sinónimos:

Acetylsalicylic acid, 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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About This Item

Fórmula lineal:
2-(CH3CO2)C6H4CO2H
Número de CAS:
50-78-2
Peso molecular:
180.16
Beilstein:
779271
Número CE:
200-064-1
Número MDL:
MFCD00002430
Código UNSPSC:
12352106
ID de la sustancia en PubChem:
24890623
NACRES:
NA.21
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Agency

USP/NF
meets USP testing specifications

Nivel de calidad

200

Formulario

powder or crystals

mp

134-136 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

cadena SMILES

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

Clave InChI

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Información sobre el gen

human ... ITGA2B(3674) , PTGS1(5742) , PTGS2(5743)

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Descripción general

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug.[1][2] It occurs as white crystalline powder[2] and is derived from salicylic acid.[2]

Aplicación

Aspirin has been used:
  • as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement[3]
  • to evaluate cell viability of BV-2 microglial cell line[4]
  • in morphogenesis assay[5]

Acciones bioquímicas o fisiológicas

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis.[6] It is also associated with cardiovascular diseases.[6]
Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

482.0 °F

Punto de inflamabilidad (°C)

250 °C

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
MKCW1182
0000237091
0000216819
0000216819
0000237091

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Visite la Librería de documentos

Relationship between endotoxin and prostaglandin (PGE2 and PGFM) concentrations and ovarian function in dairy cows with puerperal endometritis
Mateus L, et al.
Animal Reproduction Science (2003)
Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling
Henry, et al.
Cancer Research, 77(3), 790-801 (2017)
Acetylsalicylic acid enhances the anti-inflammatory effect of fluoxetine through inhibition of NF-kB, p38-MAPK and ERK1/2 activation in lipopolysaccharide-induced BV-2 microglia cells
Yang JM, et al.
Neuroscience, 275, 296-394 (2014)
The 100 Most Important Chemical Compounds: A Reference Guide (2011)
Concise Clinical Pharmacology (2007)
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. How to dissolve Aspirin and minimize concentration for storage?

    1 answer

    1. This compound is soluble in ethanol at 50 mg/mL, in water at 3 mg/mL, and in 37 °C water at 10 mg/mL. Acetylsalicylic acid is not stable in aqueous solutions and will readily hydrolyze to salicylic acid. Minimal concentration and solution stability in ethanol have not been established.

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