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Key Documents

PHR1309

Supelco

Dimethyl Sulfoxide

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Sulfoxide, DMSO

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About This Item

Número de CAS:
EC Number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to Ph. Eur. D2050000
traceable to USP 1211006

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

Inchi Key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Dimethyl Sulfoxide (DMSO) is an amphipathic molecule and contains both highly polar and apolar groups, making it an efficient solvent as it can dissolve in both aqueous and organic solvents. It has its therapeutic use in the treatment of a variety of human conditions such as brain edema, amyloidosis, interstitial cystitis, and schizophrenia. It is a commonly used solvent for hydrophobic pharmaceutical agents, exhibiting effective hydroxyl radical scavenging ability. Commercially it is produced by oxidation of dimethylsulfide (DMS) with dinitrogen tetroxide. It is a component of a wide variety of foodstuffs and beverages.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA0526 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup


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Application of nuclear magnetic resonance spectroscopy for quantitative analysis of miconazole, metronidazole and sulfamethoxazole in pharmaceutical and urine samples
Salem AA, et al.
Journal of Pharmaceutical and Biomedical Analysis, 41(2), 654-661 (2006)
Farhana Musarrat et al.
Journal of medical virology, 92(10), 2087-2095 (2020-05-07)
Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is the causative agent of the coronavirus disease-2019 (COVID-19) pandemic. Coronaviruses enter cells via fusion of the viral envelope with the plasma membrane and/or via fusion of the viral envelope with endosomal membranes
Solvation and ion pairing of alkali-metal alkoxides in dimethyl sulfoxide. Conductometric studies
Exner JH and Steiner EC
Journal of the American Chemical Society, 96(6), 1782-1787 (1974)
Room temperature ionic liquid as matrix medium for the determination of residual solvents in pharmaceuticals by static headspace gas chromatography
Liu F and Jiang Y
Journal of Chromatography A, 1167(1), 116-119 (2007)
Protective effects of the free radical scavengers, dimethyl sulfoxide and ethanol, in cerebral ischemia in gerbils
Phillis JW, et al.
Neuroscience Letters, 244(2), 109-111 (1998)

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