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T-075

Supelco

3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Sinónimos:

3,3′,5′-Triiodo-L-thyronine, Reverse T3, rT(3)

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About This Item

Fórmula empírica (notación de Hill):
C15H12I3NO4
Número de CAS:
5817-39-0
Peso molecular:
650.97
Número MDL:
MFCD00036864
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329826619
NACRES:
NA.24

grado

certified reference material

Formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

100 μg/mL in methanol with 0.1N NH3

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing
clinical testing

Formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

N[C@@H](Cc1ccc(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1

Clave InChI

HZCBWYNLGPIQRK-LBPRGKRZSA-N

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Descripción general

Reverse T3, also known as rT3 or 3,3′,5′-Triiodo-L-thyronine, is a biologically inactive form of the thyroid hormone T3 and is produced in the body particularly during periods of stress. Under certain conditions such as fibromyalgia, liver disease, and chronic fatigue syndrome (CFS), more rT3 is produced which minimizes the desirable conversion of thyroxine (T4) to T3. Reverse T3 serum concentrations are measured by LC-MS/MS to monitor impact of these and other diseases on thyroid hormone levels.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Bernt Rønning et al.
The Journal of experimental biology, 212(19), 3060-3067 (2009-09-15)
Young birds, in their post-natal growth period, may reduce their growth and metabolism when facing a food shortage. To examine how such responses can be mediated by endocrine-related factors, we exposed Japanese quail chicks to food restriction for either 2
Davide Gnocchi et al.
Steroids, 77(6), 589-595 (2012-03-01)
Thyroid hormones (THs) have a wide variety of essential roles in vertebrates, ranging from the regulation of key metabolic processes to cell proliferation and apoptosis. The classical mechanism of action of THs is genomic; 3,5,3'-triiodothyronine (T3) binds to specific nuclear
Hidenori Nagao et al.
The Journal of endocrinology, 210(1), 117-123 (2011-04-12)
Little is known about the kinetics and metabolism of thyroid hormones in the hypothyroid state. To investigate these factors, we developed a reliable method for measurement of serum thyroxine (T(4)), triiodothyronine (T(3)), reverse-T(3) (rT(3)) and stable isotope-labeled T(4) ([(13)C(9)]T(4)), using
Elena Grasselli et al.
The Journal of endocrinology, 210(1), 59-69 (2011-04-22)
Iodothyronines influence lipid metabolism and energy homeostasis. Previous studies demonstrated that 3,5-l-diiodothyronine (T(2)), as well as 3,3',5-L-triiodothyronine (T(3)), was able to both prevent and reverse hepatic steatosis in rats fed a high-fat diet, and this effect depends on a direct
[Total triiodothyronine (TT3), free triiodothyronine (FT3), reverse T3 (rT3)].
Tamio Ieiri
Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 7, 284-289 (2010-10-22)
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Protocolos

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

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