In vitro & molecular toxicology, 13(2), 113-123 (2000-10-14)
Contact sensitivity is a T-cell-mediated immune disease that can occur when low-molecular-weight chemicals penetrate the skin. In vivo topical application of chemical sensitizers results in morphological modification of Langerhans cells (LC). Moreover, within 18 h, LC increase their major histocompatibility
We report a case of contact dermatitis of the ear canal due to rubber earplugs. A 31-year-old Japanese woman had a 2-year history of eczema confined to her ears. Applications of various topical steroids had shown no beneficial effect upon
At evaluation of contact dermatitis caused by solid material, patch testing is usually performed with the material as such and with extracts of it. In this study, optimization of the extraction technique monitored by quantitative HPLC analysis of the extracted
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