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Merck

935441

Sigma-Aldrich

Aldehyde functionalized hyaluronic acid

Degree of functionalization ~20%

Sinónimos:

HA-A, Hyaluronic acid, Hyluronic acid aldehyde, Oxidized hyaluronic acid

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About This Item

Fórmula lineal:
(C14H20NNaO11)n(C14H18NNaO11)m
UNSPSC Code:
12352201
NACRES:
NA.28

Quality Level

form

powder or chunks (or fibers)

color

white to off-white

storage temp.

−20°C

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General description

Hyaluronic acid (HA) is an important component of the natural extracellular matrix which plays a vital role in various cellular and tissue functions. It represents some unique properties such as excellent gel-forming properties and chemical modification ability through hydroxyl and carboxyl groups that make them potentially useful for their application in Tissue engineering. Partially oxidized hyaluronate (OHA) containing two highly aldehyde groups in the repeating unit of HA. The dialdehyde groups of OHA are capable of reductive coupling with primary amines and thus can be used in a wide range of chemical modifications of HA as hydrogel for tissue engineering applications and regenerative medicine drug delivery applications

Application

HA is increasingly used for a many biomedical applications because it promotes cell migration, angiogenesis, cell viability, and proliferation. Aldehyde functionalized HA can be used to develop hydrogels for tissue engineering, regenerative medicing, bioprinting, and drug delivery applications.

Features and Benefits

  • Coupling capabilities with primary amines
  • Biocompatible functionalized natural polymer
  • Promotes a variety of cellular and tissue functions

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Visite la Librería de documentos

Strategies for Hyaluronic Acid-Based Hydrogel Design in Drug Delivery
Sonia T, et al.
Pharmaceutics, 11, 407-407 (2019)
Oxi-HA/ADH Hydrogels: A Novel Approach in Tissue Engineering and Regenerative Medicine
Franca G C, et al.
Polysaccharides, 2, 477-496 (2021)
Modified hyaluronic acid-based materials for biomedical applications
Tiwari S, et al.
International Journal of Biological Macromolecules, 121, 556-571 (2019)
General Dialdehyde Click Chemistry for Amine Bioconjugation
Elahipanah S, et al.
Bioconjugate Chemistry, 28, 1422-1433 (2017)
Hyaluronic Acid and Controlled Release: A Review
Bayer S I, et al.
Molecules (Basel), 25, 2649-2649 (2020)

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