764191

Alkyne-PEG5-N-hydroxysuccinimidyl ester

• Sinónimos: Acetylene-PEG5-NHS ester, Alkyne-PEG5-NHS ester, Alkyne-PEG5-succinimidyl ester
• Fórmula empírica (notación de Hill): C₁₈H₂₇NO₉
• Peso molecular: 401.41
• Número MDL: MFCD22574798
• Código UNSPSC: 12352108
• ID de la sustancia en PubChem: 329767105
• NACRES: NA.22

Propiedades

• Formulario: liquid
• Nivel de calidad: 100
• idoneidad de la reacción: reaction type: click chemistry; reagent type: cross-linking reagent
• grupo funcional: NHS ester; alkyne
• temp. de almacenamiento: −20°C
• cadena SMILES: C#CCOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O
• InChI: 1S/C18H27NO9/c1-2-6-23-8-10-25-12-14-27-15-13-26-11-9-24-7-5-18(22)28-19-16(20)3-4-17(19)21/h1H,3-15H2
• Clave InChI: ACZDUKRWTPZVRP-UHFFFAOYSA-N

Descripción

Aplicación

Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable