748684

Phosgene solution

15 wt. % in toluene

• Sinónimos: Carbon oxychloride, Carbonyl chloride, Phosgen
• Fórmula lineal: COCl₂
• Número de CAS: 75-44-5
• Peso molecular: 98.92
• Beilstein: 1098367
• Número MDL: MFCD00036119
• Código UNSPSC: 12352101
• ID de la sustancia en PubChem: 329765925
• NACRES: NA.22

Propiedades

• Formulario: liquid
• Nivel de calidad: 200
• concentración: 15 wt. % in toluene
• densidad: 0.924 g/mL at 25 °C
• grupo funcional: chloro
• temp. de almacenamiento: 2-8°C
• cadena SMILES: ClC(Cl)=O
• InChI: 1S/CCl2O/c2-1(3)4
• Clave InChI: YGYAWVDWMABLBF-UHFFFAOYSA-N

Descripción

Descripción general

Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.

Aplicación

Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers:

• γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA)
• γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA)
• 2-nitrobenzyl(4-vinylphenyl)carbamate

Phosgene solution may be used in the synthesis of:

• sulfonyl chlorides
• Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride
• O-benzyl-L-serine carboxyanhydrides

Envase

The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Información legal

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Información de seguridad

• Pictogramas: GHS02,GHS06,GHS08,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H225,H304,H314,H330,H336,H361d,H373,H412
• Consejos de prudencia: P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 1 Inhalation - Aquatic Chronic 3 - Asp. Tox. 1 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2 - Skin Corr. 1B - STOT RE 2 - STOT SE 3
• Órganos de actuación: Central nervous system
• Código de clase de almacenamiento: 3 - Flammable liquids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): 39.2 °F - closed cup
• Punto de inflamabilidad (°C): 4 °C - closed cup